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The introduction of cocaine as the first local anesthetic (LA) in the late nineteenth century was soon accompanied by reports of its systemic toxicity. The symptoms of toxicity were frequently described as seizures or respiratory failure, but some cases also included accounts of adverse cardiac effects. Often lethal, local anesthetic systemic toxicity (LAST) was treated with caffeine, ammonia, or even hypodermic ether. The development of procaine in 1904 did not solve the problem of systemic toxicity, and the Committee for the Study of Toxic Effects of Local Anesthetics published a report of 43 fatal cases linked to the use of LAs. Identification of contributing factors, emphasis on prevention and the almost-complete elimination of cocaine from clinical practice helped decrease the incidence of LAST for nearly 50 years.

Local Anesthetic Agents Cheat Sheet from Carmilaa.

Part 1 in our series on anesthetic monitoring The authors answer questions about why and how to provide cutting-edge anesthesia for your patients.

Anesthetic Gases: Guidelines for Workplace Exposures These guidelines are not a new standard or regulation, and they create no new legal obligations. The guidelines are advisory in nature, informational in content, and are intended to assist employers in providing a safe and healthful workplace through effective prevention programs adapted to the needs of each place of employment. These guidelines are not intended to address issues to patient care.

Anesthetic Management of Charcot-Marie-Tooth Disease. PubMed, SCI, Scopus, ESCI, PMC indexed

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Presently the acceptable way of sorting, weighing and injecting (medications/vaccines) live fish is by anesthetize them before handling. A common method of e...

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Anesthetic Considerations for Patients with Aortic Valve Stenosis | Calgary Guide

Part 2 in our three-part series discussing the goals of anesthetic monitoring as well as associated procedures and equipment.

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