The 2025 CPT manual introduces 16 new telemedicine codes designed for real-time encounters, which are divided into those conducted via synchronous audio-video connection and audio-only connection. These codes mirror the structure of office and outpatient evaluation and management (E/M) codes. It is essential to note that the services must be provided by a physician or qualified healthcare professional (QHP), and code selection depends on whether the patient is new or established and the method used for determining the level of service, either through medical decision-making (MDM) or time spent on the encounter.