English Uses Using In spite of & Despite, Definition and Examples In spite of and despite express a contrast between two things. They are prepositional expressions. Followed by a noun phrase or pronoun or a verb in the ‘ing’ from. Example Sentences I love his despite his faults. The young men said that they would do it despite all of the difficulties. They went out in spite of the rain. Despite being a millionaire, she lives in a very small flat. The house will certainly sell in spite of the fact that it’s overpriced. In spite of the fack that