English How to use In spite of, Using In Spite Of in English, Example Sentences with In Spite Of Using In Spite Of ” In spite of ” is used to describe an unexpected situation. Although, even though and though while connecting two sentences, ” in spite of ” does not connect two sentences. The name should come after “in spite of”. If full sentence has come, this structure cannot be used. This structure is used to describe an unexpected situation. There must be a contrast in the sentence. If the verb should come after this structure, the verb is