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Download scientific diagram | The glycolysis, pentose phosphate pathway, fatty acid synthesis, tricarboxylic acid cycle, malate/pyruvate cycle, sterol, glycerophospholipid, sphingolipid and glycerolipid synthesis pathways are outlined. Lipids detected by lipidomics are highlighted in yellow. Enzyme names are indicated and followed in parentheses by the number of genes encoding them. Enzymes conventionally thought to occur in a given pathway but for which homologs were not found in M. alpina are followed by a question mark. Hexokinase (HK, EC2.7.1.1), glucose-6-phosphate 1-dehydrogenase (G6PD, EC1.1.1.49), 6-phosphogluconolactonase (PGLS, EC3.1.1.31), phosphogluconate dehydrogenase (PGD, EC1.1.1.44), ribose 5-phosphate isomerase (RPIA, EC5.3.1.6), ribulose-5-phosphate-3-epimerase (RPE, EC5.1.3.1), transketolase (TKT, EC2.2.1.1), transaldolase (TALDO, EC2.2.1.2), glucose-6-phosphate isomerase (GPI, EC5.3.1.9), phosphofructokinase (PFK, EC2.7.1.11), fructose-bisphosphatase (FBP, EC3.1.3.11), aldolase A fructose-bisphosphate (ALDOA, EC4.1.2.13), glyceraldehyde 3-phosphate dehydrogenase (GAPDH, EC1.2.1.12), phosphoglycerate kinase (PGK, EC2.7.2.3), triose-phosphate isomerase (TPI, EC5.3.1.1), phosphoglycerate mutase (PGAM, EC5.4.2.1), enolase (ENO, EC4.2.1.11), pyruvate kinase (PK, EC2.7.1.40), lactate dehydrogenase (LDH, EC1.1.1.27), phosphoenolpyruvate carboxykinase (PCK, EC4.1.1.32 and EC4.1.1.49), acetyl-CoA carboxylase (ACC, EC6.4.1.2), malonyl-CoA decarboxylase (MLYCD, EC4.1.1.9), fatty acid synthase (FASN, EC2.3.1.86), acyl-CoA synthetase (ACSL, EC6.2.1.3), acyl-CoA thioesterase (ACOT, EC3.1.2.27), fatty acid elongase (ELOVL, EC2.3.1.-), fatty acid delta 9 desaturase (FADS9, EC1.14.19.1), fatty acid delta 12 desaturase (FADS12, EC1.14.19.6), fatty acid delta 15 desaturase (FADS15, EC1.14.19.-), fatty acid delta 6 desaturase (FADS6, EC1.14.19.3), fatty acid delta 5 desaturase (FADS5, EC1.14.19.-), malate dehydrogenase (MDH, EC1.1.1.37), malic enzyme (ME, EC1.1.1.40), pyruvate carboxylase (PC, EC6.4.1.1), ATP-citrate lyase (ACLY, EC2.3.3.8), pyruvate dehydrogenase (PDH, EC1.2.4.1), dihydrolipoamide acetyltransferase (DLAT, EC2.3.1.12), citrate synthase (CS, EC2.3.3.1), aconitase (ACO, EC4.2.1.3), isocitrate dehydrogenase (IDH, EC1.1.1.41 and EC1.1.1.42), glutamate dehydrogenase (GLUD, EC1.4.1.2 and EC1.4.1.3), 2-oxoglutarate dehydrogenase (OGDH, EC1.2.4.2), dihydrolipoamide succinyltransferase (DLST, EC2.3.1.61), succinyl-CoA ligase (SUCLG, EC6.2.1.4 and EC6.2.1.5), succinate dehydrogenase (SDH, EC1.3.5.1), fumarase (FH, EC4.2.1.2), acetyl-CoA acetyltransferase (ACAT, EC2.3.1.9), hydroxymethylglutaryl-CoA synthase (HMGCS, EC2.3.3.10), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR, EC1.1.1.34), mevalonate kinase (MVK, EC2.7.1.36), phosphomevalonate kinase (PMVK, EC2.7.4.2), mevalonate pyrophosphate decarboxylase (MVD, EC4.1.1.33), isopentenyl diphosphate isomerase (IDI, EC5.3.3.2), farnesyl diphosphate synthase (FDPS, EC2.5.1.10), farnesyl-diphosphate farnesyltransferase (FDFT, EC2.5.1.21), squalene epoxidase (SQLE, EC1.14.99.7), cycloartenol synthase (CAS, EC5.4.99.8), delta24-sterol methyltransferase (SMT, EC2.1.1.41), cycloeucalenol cycloisomerase (CEI, EC5.5.1.9), sterol 14-demethylase/cytochrome p450 family 51 (CYP51, EC1.14.13.70), delta14-sterol reductase/(ERG24, EC1.3.1.70), cholestenol isomerase/emopamil binding protein (EBP, EC5.3.3.5), sterol C5 desaturase (SC5DL, EC1.14.21.6), 7-dehydrocholesterol reductase (DHCR7, EC1.3.1.21), lanosterol synthase (LSS, EC5.4.99.7), C4 sterol methyl oxidase (SMO, EC1.14.13.72), hydroxysteroid (3-beta) dehydrogenase (HSD3B, EC1.1.1.170), hydroxysteroid (17-beta) dehydrogenase (HSD17B, EC1.1.1.270), serine palmitoyltransferase (SPTLC, EC2.3.1.50), 3-ketodihydrosphingosine reductase (KDSR, EC1.1.1.102), alkaline ceramidase (ACER, EC3.5.1.23), ceramide synthetase (CERS, EC2.3.1.24), sphingolipid delta-4 desaturase/degenerative spermatocyte homolog (DEGS, EC1.14.-.-), phosphatic acid phosphatase (PPAP, EC3.1.3.4), ceramide kinase (CERK, EC2.7.1.138), sphingomyelin phosphodiesterase (SMPD, EC3.1.4.12), sphingomyelin synthase (SGMS, EC2.7.8.27), UDP-glucose ceramide glucosyltransferase (UGCG, EC2.4.1.80), glucosylceramidase (GLCM, EC3.2.1.45), sphingosine kinase (SPHK, EC2.7.1.91), sphingosine-1-phosphate lyase (SGPL, EC4.1.2.27), CDP-diacylglycerol synthase (CDS, EC2.7.7.41), CDP-diacylglycerol inositol 3-phosphatidyltransferase (CDIPT, EC2.7.8.11), phosphatidylserine synthase (PTDSS, EC2.7.8.8), phosphatidylethanolamine methyltransferase (PEMT, EC2.1.1.17), phosphatidylserine decarboxylase (PISD, EC4.1.1.65), choline/ethanolamine phosphotransferase (CEPT, EC2.7.8.1), phospholipase C (PLC, EC3.1.4.3), glycerate kinase (GLYCTK, EC2.7.1.31), aldehyde dehydrogenase (ALDH, EC1.2.1.3), alcohol dehydrogenase (ADH, EC1.1.1.2), glycerol kinase (GK, EC2.7.1.30), glycerol-3-phosphate dehydrogenase (GPD, EC1.1.1.8), glycero-3-phosphate acyltransferase (GPAT, EC2.3.1.15), 1-acylglycerol-3-phosphate acyltransferase (AGPAT, EC2.3.1.51), phospholipase D (PLD, EC3.1.4.4), diacylglycerol kinase (DGK, EC2.7.1.107), diacylglycerol acyltransferase (DGAT, EC2.3.1.20), phospholipid diacylglycerol acyltransferase (PDAT, EC2.3.1.158), triglyceride lipase (GL, EC3.1.1.3). from publication: Genome Characterization of the Oleaginous Fungus Mortierella alpina | Mortierella alpina is an oleaginous fungus which can produce lipids accounting for up to 50% of its dry weight in the form of triacylglycerols. It is used commercially for the production of arachidonic acid. Using a combination of high throughput sequencing and lipid... | Mortierella, Lipogenesis and Lipids | ResearchGate, the professional network for scientists.
