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Targeted multidrug-resistance reversal in tumor based on PEG-PLL-PLGA polymer nano drug delivery system Liting Guo,1 Haijun Zhang,1 Fei Wang,1 Ping Liu,1 Yonglu Wang,1,2 Guohua Xia,1 Ran Liu,1 Xueming Li,2 Haixiang Yin,2 Hulin Jiang,3 Baoan Chen1 1Department of Hematology and Oncology (Key Department of Jiangsu Medicine), The Affiliated Zhongda Hospital, Medical School of Southeast University, 2School of Pharmacy, Nanjing University of Technology, 3Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of ChinAbstract: The study investigated the reversal of multidrug resistance (MDR) and the biodistribution of nanoparticles (NPs) that target leukemia cells in a nude mice model via a surface-bound transferrin (Tf). The cytotoxic cargo of daunorubicin (DNR) and tetrandrine (Tet) was protected in the NPs by an outer coat composed of polyethylene glycol (PEG)-poly-l-lysine (PLL)-poly(lactic-co-glycolic acid) (PLGA) NPs. Injection of DNR-Tet-Tf-PEG-PLL-PLGA NPs into nude mice bearing MDR leukemia cell K562/A02 xenografts was shown to inhibit tumor growth, and contemporaneous immunohistochemical analysis of tumor tissue showed the targeted NPs induced apoptosis in tumor cells. Targeted tumor cells exhibited a marked increase in Tf receptor expression, with noticeable decreases in P-glycoprotein, MDR protein, and nuclear factor κB, as assessed by quantitative real-time polymerase chain reaction and Western blot analysis. Moreover, the concentration of DNR was shown to increase in plasma, tumor tissue, and major organs. Flow cytometry analysis with a near-infrared fluorescent (NIRF) dye, NIR797, was used to study the effectiveness of Tf as a targeting group for leukemia cells, a finding that was supported by NIRF imaging in tumor-bearing nude mice. In summary, our studies show that DNR-Tet-Tf-PEG-PLL-PLGA NPs provide a specific and effective means to target cytotoxic drugs to MDR tumor cells. Keywords: PEG-PLL-PLGA nanoparticles, transferrin, tetrandrine, multidrug resistance
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Detalles de boda originales y útiles: plantas, bolsas de tela, licores, miel, velas, galletas personalizadas… ¿Con cuál os quedáis?
Sedum 'Matrona' is een vaste plant die in de nazomer tot herfst bloeit met een indrukwekkende massa kleine roze bloemen. Deze vetplant is geschikt voor droge en zonnige plekken in de tuin. Sedum 'Matrona' is een uitstekende keuze voor een onderhoudsarme, ecologische tuin omdat ze massa's vlinders trekt. Deze plant groe
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Dormitorio acogedor ★ Descubre cómo puedes redecorar tu dormitorio para los meses más fríos del año. ¡Inspírate con nosotros! ▷
Wonderland Diseños | 🙌🏼 Les presentamos el DIARIO DE BODA totalmente personalizado 😍🫶🏼. Imaginá la sorpresa de tus invitados al recibir un diario lleno de... | Instagram
Siete alla ricerca di un modo per decorare con allegria e raffinatezza il vostro matrimonio? Affidatevi ai girasoli! In questo articolo trovate 10 modi per utilizzare al meglio questo fiore così solare e stupire i vostri ospiti con addobbi unici!
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We take a virtual tour of "Stylistics," a new exhibit of photographs by the legendary "Self-Service" magazine founder Ezra Petronio.
4.9 out of 5 stars - Shop Minimalist Matron of Honor Bridal Shower Button created by FreshAndYummy. Personalize it with photos & text or purchase as is!
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Знаменитая российская актриса театра и кино Мария Миронова в настоящее время наслаждается отпуском в Италии и делится со своими подписчиками фотографиями с отдыха на страницах социальных сетей интернета. На этих снимках, которые артистка часто выкладывает в Сети, можно увидеть актрису в компании
This Digital Drawings & Illustrations item by mattiedotdk has 273 favorites from Etsy shoppers. Ships from United States. Listed on 19 Jul, 2024
