It’s possible to use 3D printing to create microfluidic devices, which are tiny ‘lab on a chip’ tools that use microscopic channels to work out small structures like cells and...
Greg Cooksey - Laminar flow patterns of dyes moving through a microfluidic device
Isolating high-quality motile sperm cells is considered to be the main prerequisite for a successful artificial pregnancy. Microfluidics has emerged as a promising platform capable of mimicking in-vivo environments to separate motile sperm cells and bypassing the need for the current invasive clinical sperm separation methods. In this study, the proposed microfluidic device exploits the parallelization concept through symmetry to increase both the processed sample volume and the injected flow rate compared with the previous conventional devices, which used rheotaxis as their primary method of sperm separation. Using the finite element method (FEM) and flow simulations, the trajectories of sperm cells exhibiting rheotaxis behavior were predicted inside the proposed device. Different flow rates, including 0, 0.5, 1.5, 3, 4.5 and 6 μl/min, were experimentally injected into the device, and the effect of flow rate on the size of the hypothetical rheotaxis zone and the number of isolated sperm cells was investigated. Furthermore, it was illustrated that 100% of the isolated motile sperm cells are motile, and by manipulating the injected flow rate into the device, different classes of sperm cells in terms of motility parameters can be separated and utilized for further uses.
Organ-on-a-chip (OOC) - microfluidic device chip that simulates biological organs that is type of artificial organ. Prototype of design lab-on-a-chip in microfl
Flow test series videos for the microfluidic lab-on-a-chip on www.uFluidic.com https://www.ufluidic.com/collections/microfluidic-chips/products/dg-dropseq-z120-droplet-microfluidics-chip
A high school physics teacher has invented a method of producing microfluidic devices, using little else than a photocopier and transparency film.
A research team has developed a first-of-its-kind soft, flexible microfluidic device that easily adheres to the skin and measures the wearer's sweat to show how his or her body is responding to exercise.
Organ-level physiology is recapitulated in vitro by culturing cells in perfused, microfluidic devices. An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments and vascular perfusion of the body, these devices produce levels of tissue and organ functionality not possible with conventional 2D or 3D culture systems. They also enable high-resolution, real-time imaging and in vitro analysis of biochemical, genetic and metabolic activities of living cells in a functional tissue and organ context. This technology has great potential to advance the study of tissue development, organ physiology and disease etiology. In the context of drug discovery and development, it should be especially valuable for the study of molecular mechanisms of action, prioritization of lead candidates, toxicity testing and biomarker identification.
Instead of running tests on live kidneys, researchers at Binghamton, University State University of New York have developed a model kidney for working out the kinks in medicines and treatments. Developed by Assistant Professor Gretchen Mahler and Binghamton biomedical engineering alumna Courtney Sakolish PhD ’16, the reusable, multi-layered and microfluidic device incorporates a porous growth substrate, with a physiological fluid flow, and the passive filtration of the capillaries around th
Miniaturized devices such as microsensors often require an independent, equally miniaturized power supply. Searching for suitable systems, Japanese scientists have now developed a fully integrated microfluidic device that produces hydrogen fuel and converts it into electrical energy based on photocatalysis. As they report in the journal Angewandte Chemie, it works fully autonomously and delivers enough hydrogen energy to power a microsensor for daily data transmission.
A handheld diagnostic device that Massachusetts General Hospital (MGH) investigators first developed to diagnose cancer has been adapted to rapidly diagnose tuberculosis (TB) and other important infectious bacteria. Two papers appearing in the journals Nature Communications and Nature Nanotechnology describe portable devices that combine microfluidic technology with nuclear magnetic resonance (NMR) to not only diagnose these important infections but also determine the presence of antibiotic-resistant bacterial strains.
The Sandia Digital Microfluidic Hub — a droplet-handling router — enables the interconnection of diverse processing and analysis modules to automate complex ...
Video related to research article appearing in Lab on a Chip. Anthony K Au et al., "3D-Printed Microfluidic Automation". Read the article at http://xlink.rsc...
A fabrication process can produce self-heating microfluidic devices in one step using a multimaterial 3D printer. These devices, which can be made rapidly and cheaply in large numbers, could help clinicians in remote parts of the world detect diseases without expensive lab equipment.
Animals often fail to faithfully mimic human diseases and drug toxicities, and most in vitro models are not complex enough to recapitulate human body function and pathophysiology. Organ-on-chip culture technology, however, offers a promising tool for the study of tissue development and homeostasis, which has brought us one step closer to performing human experimentation in vitro. To recapitulate the complex functionality of multiple organs at once, their respective on-chip models can be linked to create a functional human body-on-chip platform.
Technical collection
A moodboard by Adrian Perez on Behance
A microfluidic chip is a set of micro-channels etched or molded into a material (glass, silicon or polymer such as PDMS, for PolyDimet...
Difference Between Device Driver and Device Controller
