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Has your kidney started to deteriorate? It is important to recognize the 7 signs that your kidneys may be in danger so that you can act fast and get treated.
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If you see crescents but all the IF is negative and no deposits are seen, it's pauci-immune crescentic GN and MOST are a/w ANCA.
Membranoproliferative GN has the "train tracks" double contour. This is the one that might show sub-ENDOTHELIAL or mesangial depositis on EM. Primary form common in kids, secondary in adults.
MPGN = nephrotic
Helpful. IgA
Lupus nephritis. Histological special stains useful for delineating extent of glomerular deposits. (A) showing mesangial hypercellularity. (B) showing heavy deposits in the mesangium and capillary loops. (C) Fuchsinophilic deposits on capillary loops seen in a Masson’s trichrome-stained section. (D) Deposits in a Masson’s trichrome-stained section. (E) Deposits seen in a PAS-stained section. (F) Basement membrane “spikes” in capillary loop deposits seen in a methenamine silver-stained section.
Diabetic nephropathy = Kimmelstiel-Wilson nodular sclerosis, hyaline arterioles
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