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Richard Staines August 7, 2018 Denmark’s Lundbeck is bringing a third potential drug for Parkinson’s disease to the clinic – a human antibody that the company hopes will tackle the underlying cause of the condition. The compound known as Lu AF82422 was invented by Lundbeck in collaboration with Genmab, the company that also developed Janssen’s blood cancer drug Darzalex (daratumumab). According to Lundbeck Lu AF82422 is a human antibody targeting the toxic proteins causing the death of the dopamine-producing brain cells that leads to Parkinson’s disease. The compound is thought to work like the body’s natural antibodies when the immune system works to remove harmful proteins. As it targets the underlying biology of the disease, Lu AF82422 may potentially not only treat its symptoms, but might also slow or stop its progression. The first ever antibody that Lundbeck has brought into clinical development, in the phase 1 study it will be studied in both healthy volunteers and patients with Parkinson’s disease. Lundbeck has already added two other potential Parkinson’s drugs to its pipeline this year: Lu AF28996 and foliglurax. The Danish pharma also began developing Lu AF764323 for schizophrenia and Alzheimer’s disease this year. There is a desperate need for new drugs for Parkinson’s – with only a handful of drugs being approved in the last decade. Sunovion’s under-the-tongue film APL-130277 is close to the market, after hitting its target in a late-stage trial by improving motor function compared with placebo. The FDA last year approved Newron’s Xadago (safinamide) as an add-on treatment for patients taking levodopa/carbidopa and are experiencing “off” episodes, following a five-year battle with the regulator. Xadago was approved in Europe in 2015. Acadia’s Nuplazid, which treats hallucinations and delusions caused by the disease, was FDA-approved in 2016 but there are concerns about its safety. UK biotech e-Therapeutics this year began working with genomics firm C4X Discovery to develop new therapies for Parkinson’s. https://pharmaphorum.com/news/lundbeck-brings-third-parkinsons-drug-into-clinic/
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October 31, 2017 The NIH BRAIN Initiative has awarded two Cleveland Clinic researchers grants to study ethical issues involving brain surgery, as part of the first neuroethics grants awarded by the initiative. Cynthia Kubu, PhD, a neuropsychologist in the Center for Neurological Restoration at Cleveland Clinic, was awarded $1.6 million over four years to study patients' and family members' perspectives regarding personality in the context of Parkinson's disease and deep brain stimulation (DBS) for the condition. The study, funded by the National Institute of Mental Health as part of the National Institute of Health's BRAIN Initiative, will focus on patients' and family members' perspectives regarding the personality characteristics they value most and changes in those personality characteristics at different stages of Parkinson's and over the course of DBS. "We hypothesize that patients will report changes to personality associated with Parkinson's Disease," Dr. Kubu said, "Conversely, we think that deep brain simulation will result in a return to pre-illness personality and will allow patients to be their more authentic self." The data from the study will identify if existing measures capture valued personality characteristics, illustrate if Parkinson's disease results in changes in perceived personality, demonstrate the concordance between patients' and families' ratings of perceived personality change, and confirm if DBS results in changes in individually meaningful personality characteristics. Researchers believe these data have implications for the development of personality measures that mirror patients' values, the informed consent process, and may inform public and philosophical discussions of identity and autonomy in the context of deep brain stimulation. In addition, Lauren Sankary, J.D., a neuroethics fellow at Cleveland Clinic, was awarded a three-year grant through the BRAIN Initiative Fellows program to study ethical issues arising as research participants exit investigational studies of implanted brain devices. Sankary's neuroethics research will take place under an NIH Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship grant. Her research focuses on the experiences of research participants at the end of their participation in clinical trials of two implanted brain devices: deep brain stimulation (DBS) and closed-loop responsive neurostimulation (RNS). This research will draw from data from completed DBS clinical trials and will include ongoing involvement in the Cleveland Clinic's novel clinical trial of DBS for stroke recovery. "As medicine moves forward with technologies that allow us to treat patients in new ways in the field neuroscience, we must have a firm understanding of the ethics surrounding these advances," said Paul Ford, Ph.D, interim chair of the Department of Bioethics at the Cleveland Clinic. "We are thankful the BRAIN Initiative sees the importance of exploring ethical considerations in neuroscience and hope our contributions can help move the field forward." Source: https://my.clevelandclinic.org/ https://www.news-medical.net/news/20171031/Cleveland-Clinic-researchers-win-grants-to-study-ethical-issues-involving-brain-surgery.aspx
Parkinson’s Institute and Clinical Center and Retrotope established a new collaboration to evaluate RT001 in patients with progressive supranuclear palsy.
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You may already know that yoga is a great way to get moving, but could it also help with Parkinson's symptoms? Here's how it works, poses to try, and more.
Parkinson's disease is a neurological disorder that affects motor function. Symptoms include tremors, bradykinesia, rigidity, and postural instability.
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Ever wonder how do Parkinson’s medications work? Parkinson’s medications work by restoring the level of dopamine in the brain. Dopamine is a neurotransmitter that is deficient in the brain of PD.
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BY RYAN BOETEL / JOURNAL STAFF WRITER Monday, April 15th, 2019 ALBUQUERQUE, N.M. — Former University of New Mexico regent Jamie Koch learned there was a months-long waiting list to see a movement disorder specialist when his doctor told Koch he probably had Parkinson’s disease. He has since become an advocate for creating a clinic at UNM that will bring together resources to help treat Parkinson’s and other movement disorders. Partial funding for such a center was included in a state spending bill, and doctors at the university hospital are hopeful the complex will be up and running by late summer or early fall 2020. “This movement center won’t benefit me now. I know I have Parkinson’s and I know what I have to do and my doctor has me on a good schedule,” Koch said in an interview. “But people who don’t know they have it … or somebody who doesn’t have much money and it would take nine months to determine if they have Parkinson’s, what are they going to do? That’s why I pushed so hard.” Support for the center has gained momentum. The 2018 Legislature passed a memorial urging the UNM Health Sciences Center to explore the creation of a movement disorders center. In 2019, funding was allocated to design and construct the center. Koch noted that there was bipartisan support for the project. The state spending bill signed by the governor contains $3.5 million in state funding for the project, and the University of New Mexico has pledged to match that funding, according to a UNM news release. With that $7 million, university officials are planning a 16,000-square-foot, single-story clinic. Planning documents show the clinic would have nearby parking to make for easy access to the clinic, wide hallways and space dedicated for therapy and rehabilitation. The exact location for the facility hasn’t been finalized. “Parkinson’s is a progressive problem. There’s ways you can slow it down with the proper medicine, the proper exercise and the proper program,” Koch said. “If you have to wait nine months to determine if you have Parkinson’s and then once you get Parkinson’s it might be six months before you can get in with your doctor because they are so busy … (the center) will mean that people can get treated quickly instead of having to wait for a long time.” Dr. Sarah Pirio Richardson, a UNM neurologist who specializes in movement disorders, said in addition to bringing together many of the university resources that could help people with Parkinson’s and other movement disorders, the clinic will hopefully also attract doctors. She said there are only three movement disorder specialists in the state and about 10,000 possible patients. “We need both the infrastructure and the people to do the job and take care of the vast need,” she said. Pirio Richardson said in New Mexico there is about a six- to nine-month waiting list to see a movement disorder specialist. There is no cure for Parkinson’s. People living with the disease try to manage their symptoms with a combination of medicine and physical therapies. UNM’s movement disorders clinic will be modeled like similar clinics that exist in other states. UNM’s Amanda Deligtisch, an associate professor in the Department of Neurology, is hopeful that having such a space will help the university take part in clinical trials that could help patients. “As a center one of the things you can do is start to expand your experience and footprint into clinical trials so patients in New Mexico could be part of those cures, potentially,” she said. https://www.abqjournal.com/1303168/unm-secures-funding-for-movement-disorders-clinic.html
October 4, 2017 MRI Functional MR imaging (fMRI) may help predict development of visual hallucinations in patients with Parkinson’s disease (PD), according to a study published in Radiology. Researchers from the Netherlands performed a small retrospective study to assess the pathophysiological mechanisms of visual hallucinations among patients with PD by analyzing whole-brain resting-state functional connectivity in PD patients with visual hallucinations, patients without visual hallucinations, and control participants. “Visual hallucinations in Parkinson’s disease are frequent and debilitating,” co-author Dagmar H. Hepp, MD, from the Department of Neurology and the Department of Anatomy and Neurosciences at VU University Medical Center (VUMC) in Amsterdam, said in a release. “Our aim was to study the mechanism underlying visual hallucinations in Parkinson’s disease, as these symptoms are currently poorly understood.” Fifteen patients with hallucinations, 40 patients without and 14 controls participated in the study. All underwent fMRI. Functional connectivity was calculated between 47 regions of interests, of which whole-brain and region-specific means were compared by using a general linear model with false discovery rate control for multiple comparisons. The results showed that whole-brain mean functional connectivity was significantly lower in patients with PD compared with controls, with regional decreases involving paracentral and occipital regions in patients with PD both with hallucinations and without. Among the patients, with hallucinations, nine additional frontal, temporal, occipital, and striatal regions showed decreased functional connectivity compared with the controls. The resting-state functional connectivity was unrelated to motor performance and related to cognitive deficits such as attention and perception. “We found that the areas in the brain involved in attention and visual processing were less connected to the rest of the brain,” co-author Menno M. Schoonheim, PhD, from the Department of Anatomy and Neurosciences at VUMC, said in the release “This suggests that disconnection of these brain areas may contribute to the generation of visual hallucinations in patients with Parkinson’s disease.” http://www.diagnosticimaging.com/brain-mri/mri-may-predict-visual-hallucinations-parkinson-disease
Parkinson's disease can cause a disturbance in an individual's gait, or way of walking. It is illustrated by stiffness, slowness, and trouble moving.
Here at Hosiped, we pride in exploring knowledge as well as sharing it out with others. As caregivers, we know how important it is to disseminate information in a timely, accurate manner so that others can use it to their advantage. It is because of this objective that we are always seeking new knowledge on […]
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This heart condition present at birth causes a fast heartbeat. Rarely, it can cause sudden cardiac death. Know the symptoms and how it's treated.
Alors qu'une nouvelle campagne de sensibilisation sur la maladie de Parkinson démarre, le CHU de Nantes fait naître un espoir chez les malades avec une nouvelle poste de traitement.
Parkinson's disease is a chronic and progressive neurological disorder that affects the motor system of the human body. The incidence increases with age, with the highest rates of diagnosis occurring in people over the age of 60. It is caused by the degeneration of neurons in the brain which leads to deficiency of dopamine.
April 12, 2018 New Delhi: It is estimated that about 30 million people in India suffer from various forms of neurological diseases and the average prevalence rate is as high as 2,394 patients per 1,00,000 of the population. Yet, the awareness about various forms of neurological disorders is abysmally low here and people suffering from these often end up being ridiculed and stigmatised. Due to lack of awareness and understanding, neurological disorders are often subject to various taboos, which heavily impact the lives of patients, hindering the treatment and in some cases even aggravating the problem. "There is a serious lack of awareness about Parkinson's disease or its management in India. Caused by progressive damage to parts of brain over many years, the disease shows symptoms of involuntary shaking of body parts of the body, slowing movement, and stiffness in muscles. People suffering from Parkinson's disease also experience depression and anxiety, have the sense of losing balance, memory, and sleep. It remains the second most common neurodegenerative disorder and most common movement disorder, and its onset usually is on people older than 60 years of age," said Dr. Satwant Sachdeva, Consultant Neurologist, Columbia Asia Hospital, Patiala. According to a recent study, the number of deaths due to neurological disorders increased by 36.7 per cent worldwide between 1990 and 2015. A report published in The Lancet in 2015 by the Global Burden of Disease (GBD) project, claimed that neurological diseases comprised 16.8 per cent of global deaths. On the occasion of World Parkinson's Day, Dr Vinit Suri, Senior Consultant, Neurology, Indraprastha Apollo Hospitals highlights some taboos often encountered by neurologists while treating patients. -The taboo of insanity- This is the most commonly associated taboo with people who suffer from neurological disorders. Due to lack of awareness, people often label patients suffering from Alzheimer's as 'senile' and those who have epilepsy as 'crazy'. It is not unusual to see people with neurological disorders being referred to psychiatrists to 'cure' their insanity. -The taboo of a weak mind- People generally assume that neurological disorders are the result of a weaker mind. That someone with epilepsy or Parkinson's will have less IQ than an average person, is also a myth present in our society. Children suffering from epilepsy are often treated differently from their peers, and even as adults. -The taboo of superstition - Illiteracy in India is high, due to which superstitions flourish in many parts of our country, especially the rural areas. Many a times, neurological diseases like epilepsy are associated with demonic possessions. To treat the so-called demonic possessions, the patients are put through some horrendous conditions and even physically mutilated in some instances. This again is propagated due to a lack of awareness and good quality education. -The taboo of treatment- Irrespective of the disease, a neurological disorder is perceived as untreatable. This belief is prevalent even in urban areas. Many a times, when a patient is diagnosed with a neuro-disease, he/she automatically assumes that it would be a life-long burden and there can be no cure. With the advancement in medical sciences, many therapies have worked wonderfully to cure the disorders, or at least significantly reduce their impact. -The taboo of association- Due to all the negative connotations attached to neurological disorders, people tend to stigmatise any form of association with patients suffering from these diseases. This can lead to great suffering in the social and personal lives of these patients. It is not unusual for marriages to break and children to abandon their parents in old age, to avoid bearing the brunt of taking care of these patients. http://health.einnews.com/article/441634356/OrvB795bDzR_d0YS
Parkinson’s is a progressive disease caused by the abnormal clumping of a protein in brain cells, some of which produce a chemical called dopamine that plays a vital role in […]
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The Five Stages of Parkinson’s Disease Parkinson’s Disease is a progressive neurodegenerative disease that currently does not have a cure. This past month, Parkinson’s Awareness Month, we have had the opportunity to witness our community rally to help create awareness around this disease. We are optimistic that one day there will be a cure for […]
This slide show explains the current treatments used for Parkinson’s disease (PD): medication, surgery, and supportive therapies. The goals of treatment are to manage symptoms and minimize side effects. Seeing your doctor often, having your medications adjusted regularly, and telling your doctor about changes and side effects are very important for best managing Parkinson’s disease.
Scientists believe a combination of genetic and environmental factors are the cause of Parkinson’s disease (PD). PD is an extremely diverse disorder. While no two people experience Parkinson’s the same way, there are some commonalities.
Mutations in four specific genes may help to identify those Parkinson’s patients at risk of developing the addictive behaviors known as impulse control disorders, researchers in Norway report.
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Dennis Hodge, 70, of Anderson didn’t think anything was wrong when he started having trouble getting in and out of his car.
