GEN’s first-ever A-List for synthetic biology ranks the five largest public companies by their 2020 revenues, and the five largest private companies by the total capital they have raised.
Author summary Dietary restriction extends lifespan across most organisms in which it has been tested. However, several studies have now demonstrated that this effect can vary dramatically across different genotypes within a population. Within a population, dietary restriction might be beneficial for some, yet detrimental for others. Here, we measure the metabolome of 178 genetically characterized fly strains on fully fed and restricted diets. The fly strains vary widely in their lifespan response to dietary restriction. We then use information about each strain’s genome and metabolome (a measure of small molecules circulating in flies) to pinpoint cellular pathways that govern this variation in response. We identify a novel pathway involving the gene CCHa2R, which encodes a neuropeptide receptor that has not previously been implicated in dietary restriction or age-related signaling pathways. This study demonstrates the power of leveraging systems biology and network biology methods to understand how and why different individuals vary in their response to health and lifespan-extending interventions.
When he isn’t sitting as a model for Wolfgang Tillmans and Prada, Berlin-based art director and editor Karl Kolbitz enquires into concepts that may otherwise...
Landry
Ꮲᴏsᴛᴇrs Ꮪᴀnriᴏ ᴄuᴛᴇᴄᴏrᴇ
