Mantronix

http://www.missuniverse.com/Episode 7 - Pageant Tips & Tricks. Olivia, Nana, and Logan put the "Crown Aside" and talk about some of the most interesting tips...

Targeted multidrug-resistance reversal in tumor based on PEG-PLL-PLGA polymer nano drug delivery system Liting Guo,1 Haijun Zhang,1 Fei Wang,1 Ping Liu,1 Yonglu Wang,1,2 Guohua Xia,1 Ran Liu,1 Xueming Li,2 Haixiang Yin,2 Hulin Jiang,3 Baoan Chen1 1Department of Hematology and Oncology (Key Department of Jiangsu Medicine), The Affiliated Zhongda Hospital, Medical School of Southeast University, 2School of Pharmacy, Nanjing University of Technology, 3Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of ChinAbstract: The study investigated the reversal of multidrug resistance (MDR) and the biodistribution of nanoparticles (NPs) that target leukemia cells in a nude mice model via a surface-bound transferrin (Tf). The cytotoxic cargo of daunorubicin (DNR) and tetrandrine (Tet) was protected in the NPs by an outer coat composed of polyethylene glycol (PEG)-poly-l-lysine (PLL)-poly(lactic-co-glycolic acid) (PLGA) NPs. Injection of DNR-Tet-Tf-PEG-PLL-PLGA NPs into nude mice bearing MDR leukemia cell K562/A02 xenografts was shown to inhibit tumor growth, and contemporaneous immunohistochemical analysis of tumor tissue showed the targeted NPs induced apoptosis in tumor cells. Targeted tumor cells exhibited a marked increase in Tf receptor expression, with noticeable decreases in P-glycoprotein, MDR protein, and nuclear factor κB, as assessed by quantitative real-time polymerase chain reaction and Western blot analysis. Moreover, the concentration of DNR was shown to increase in plasma, tumor tissue, and major organs. Flow cytometry analysis with a near-infrared fluorescent (NIRF) dye, NIR797, was used to study the effectiveness of Tf as a targeting group for leukemia cells, a finding that was supported by NIRF imaging in tumor-bearing nude mice. In summary, our studies show that DNR-Tet-Tf-PEG-PLL-PLGA NPs provide a specific and effective means to target cytotoxic drugs to MDR tumor cells. Keywords: PEG-PLL-PLGA nanoparticles, transferrin, tetrandrine, multidrug resistance

Excited to share the latest addition to my #etsy shop: Margarita Cartoon Sticker - Compact Vinyl Decal for Laptop, Tablet, Hydroflask - Perfect for Party Favors and Margarita Lovers https://etsy.me/46iilPc #margaritasticker #tequilasticker #cocktailstickers #margaritas

Graphic Design, Advertising, Product Design

Mantronix

Explore Sandy Mastroni’s 1,000 photos on Flickr!

Hailing from the Endangered Audio Research family, today’s featured piece of gear comes to us under the moniker of Moxtronix, and is entitled the TransTone Fuzz. This small grey beauty has a TON of options and sounds just waiting to be dialed in, explored, abused and left for dead, all of which you’ll have no […]

One of my all-time favorite groups/producers - Mantronix

I was making synths and stuff, while my girlfriend played on Youtube a Manu Chao live performance. I noticed  some familar sounds I knew from my childhood – the Executor keychain, true classic (there is also an Android app thats imitates it). I made some research and I found a specialized, proffesional device destined for […]

Mactronix logo png vector transparent. Download free Mactronix vector logo and icons in PNG, SVG, AI, EPS, CDR formats.

contemporary folk art paintings

contemporary folk art paintings

on the hutch in my dining room