Делюсь рецептом простого песочного печенья на вареных желтках. Чаще всего мы готовим выпечку на сырых яйцах, но иногда лучше воспользоваться только
והפעם מרק ירקות חורפי, כזה שהוא טיפה יותר סמיך, מעט יותר עמוס ויש בו בצקניות נפלאות קטנטנות וביחד זו ממש ארוחה. היכנסו למתכון!
לפני המון המון זמן קיבלתי משימה מנחמה שובתת לכתוב פוסט עם עשרה דברים שלא יודעים עלי ולא ביצעתי אותה… לא ידעתי מה לכתוב עבר זמן ואספתי כמה רעיונות והנה הגיע מרק כרובית ואני משתפת אתכם בעשרה דברים שרובכם לא יודע עלי: -1- בבקרים לחוצים אני מכינה לי כוס קפה ולוקחת אותה למקלחת לדעתי זה גאוני […]
Targeted multidrug-resistance reversal in tumor based on PEG-PLL-PLGA polymer nano drug delivery system Liting Guo,1 Haijun Zhang,1 Fei Wang,1 Ping Liu,1 Yonglu Wang,1,2 Guohua Xia,1 Ran Liu,1 Xueming Li,2 Haixiang Yin,2 Hulin Jiang,3 Baoan Chen1 1Department of Hematology and Oncology (Key Department of Jiangsu Medicine), The Affiliated Zhongda Hospital, Medical School of Southeast University, 2School of Pharmacy, Nanjing University of Technology, 3Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of ChinAbstract: The study investigated the reversal of multidrug resistance (MDR) and the biodistribution of nanoparticles (NPs) that target leukemia cells in a nude mice model via a surface-bound transferrin (Tf). The cytotoxic cargo of daunorubicin (DNR) and tetrandrine (Tet) was protected in the NPs by an outer coat composed of polyethylene glycol (PEG)-poly-l-lysine (PLL)-poly(lactic-co-glycolic acid) (PLGA) NPs. Injection of DNR-Tet-Tf-PEG-PLL-PLGA NPs into nude mice bearing MDR leukemia cell K562/A02 xenografts was shown to inhibit tumor growth, and contemporaneous immunohistochemical analysis of tumor tissue showed the targeted NPs induced apoptosis in tumor cells. Targeted tumor cells exhibited a marked increase in Tf receptor expression, with noticeable decreases in P-glycoprotein, MDR protein, and nuclear factor κB, as assessed by quantitative real-time polymerase chain reaction and Western blot analysis. Moreover, the concentration of DNR was shown to increase in plasma, tumor tissue, and major organs. Flow cytometry analysis with a near-infrared fluorescent (NIRF) dye, NIR797, was used to study the effectiveness of Tf as a targeting group for leukemia cells, a finding that was supported by NIRF imaging in tumor-bearing nude mice. In summary, our studies show that DNR-Tet-Tf-PEG-PLL-PLGA NPs provide a specific and effective means to target cytotoxic drugs to MDR tumor cells. Keywords: PEG-PLL-PLGA nanoparticles, transferrin, tetrandrine, multidrug resistance
Excited to share the latest addition to my #etsy shop: Margarita Cartoon Sticker - Compact Vinyl Decal for Laptop, Tablet, Hydroflask - Perfect for Party Favors and Margarita Lovers https://etsy.me/46iilPc #margaritasticker #tequilasticker #cocktailstickers #margaritas
Little trick-or-treaters need a full belly before they hit the lolly trail, so here are some freakishly fun family Halloween dinner ideas.
In questa pagina ti parlerò di rivestimenti in pietra, sia per interno che per l'esterno della tua casa. Vedremo insieme le differenze tra i rivestimenti in pietra naturale ed i rivestimenti in pietra ricostruita e potrai scorrere tra decine e decine di foto, fino a trovare l'idea o la soluzione perfetta per il rivestimento delle pareti di casa tua.
Built by Suárez Corchete in Sanlúcar de Barrameda, Spain with date 2009. Images by Fernando Alda . The planning regulations require the creation a free, unbuilt space within the plot. This premise led us to believe...
Texture seamless brick
nice space changer
#river #water #nature #aesthetic
Проект загородного дома в стиле Тюдор. Ital Project
Coleg Cambria Brick Course
