There’s never been a better time to hit up the American Southwest than now, what with Georgia O’keeffe-inspired everything, enthusiastic frenzy over the merits of mezcal and a renewed romance with the desert. Might we suggest Santa Fe? This vibrant city is a curious mix of flashy high-rises and boxy (and colorful, we might add) adobe architecture of old, filled with healing centers, spas and the tenets of a true spiritual homeland. Head here for a decidedly different city experience—an American mecca of turquoise, desert zen and a hotbed of arts and culture. Reporter: Julie Pointer Adams | Location: Sunrise Springs Resort Spa