Pyrrole disorder is a condition causing many mental and emotional problems. Pyroluria testing can easily be done to find out if that is the cause of any issues.
Pyroluria Diet : The best diet for Pyrrole Disorder. Recommended foods to eat, what foods to avoid if you have Pyrroles, and testing for Pyroluria diet
When you experience high levels of stress, vitamin B6 and zinc will be further depleted, so you may notice worsening symptoms and more anxiety.
What is Pyrrole Disorder? Pyrrole disorder, also known as pyroluria, kryptopyroluria, kryptopyrole or Mauve disorder is a biochemical imbalance involving an abnormality synthesis and metabolism of haemoglobin. It can be purely genetic, or acquired through environmental and emotional stress
Intrusive thoughts are a thing with anxiety even though they are not often talked about. It’s for this reason I shared a link to an article on Facebook recently – “The Debilitating Anxiety Symptom No One Ever Talks About” – and the response was overwhelming. I promised to do a blog to do a deeper dive […]
What is Pyrrole Disorder? Pyrrole disorder, also known as pyroluria, kryptopyroluria, kryptopyrole or Mauve disorder is a biochemical imbalance involving an abnormality synthesis and metabolism of haemoglobin. It can be purely genetic, or acquired through environmental and emotional stress
Pyroluria. Sad personal story to raise awareness. Urine test and potential healing through taking health supplements
There may be a much more significant factor at play that's pushing the trends towards emotional disturbance: early-life stressors. It’s a condition called pyroluria. Learn more about pyroluria and what you can do about it to help you heal in this article.
Pyroluria causes low levels of zinc and vitamin B6 leading to a type of anxiety characterized by social anxiety and inner tension
Niki Gratrix discusses how the stress of childhood trauma leads to the epigenetic expression of pyroluria - a condition where zinc, B6, and manganese are not metabolized properly - and how this condition is a major roadblock in detox. Niki also explains how this condition can be addressed through her research on releasing emotional trauma. Fascinating!
Pyroluria Diet : The best diet for Pyrrole Disorder. Recommended foods to eat, what foods to avoid if you have Pyrroles, and testing for Pyroluria diet
What is Pyrrole Disorder? Pyrrole disorder, also known as pyroluria, kryptopyroluria, kryptopyrole or Mauve disorder is a biochemical imbalance involving an abnormality synthesis and metabolism of haemoglobin. It can be purely genetic, or acquired through environmental and emotional stress
This questionnaire will help you identify whether you might have pyroluria, a social anxiety condition. The physical and emotional symptoms below are caused by deficiencies of vitamin B6 and zinc. When you experience high levels of stress, vitamin B6 and zinc will be further depleted, so you may notice worsening symptoms and more anxiety. Based …
A detailed description of the blood disorder Pyroluria, a condition that creates a major deficiency in Vitamin B6 and Zinc. Also discussed are associated conditions and treatment options.
If, like me, you have felt that social anxiety holds you back from the life you want to live, I want to tell you about a genetic condition called Pyroluria.
Pyrrole Disorder, also known as Pyroluria or Pyrroles, is a metabolic disorder that most commonly manifests as a mental health condition. Read on now.
What is Pyrrole Disorder? Pyrrole disorder, also known as pyroluria, kryptopyroluria, kryptopyrole or Mauve disorder is a biochemical imbalance involving an abnormality synthesis and metabolism of haemoglobin. It can be purely genetic, or acquired through environmental and emotional stress
Pyroluria is a social anxiety condition, where specific physical and emotional symptoms are caused by deficiencies of vitamin B6 and zinc. As well as feeling anxious, shy, or fearful or experiencing inner tension since childhood (and often hiding these feelings from others), digestive symptoms are common. I discuss this condition, connecting the dots with digestive […]
People with pyroluria can often relate to these symptoms: joints popping, cracking, or aching; pain or discomfort between the shoulder blades; or cartilage problems (likely due to low zinc levels). I’ll share what I know so far.
Pyrrole disorder is a condition causing many mental and emotional problems. Pyroluria testing can easily be done to find out if that is the cause of any issues.
Er….say WHAT? If you’ve never heard of the condition, pyroluria, you’re not alone. Chances are your doctor hasn’t heard of it either, or isn’t too interested in it, even if […]
Pyrrole Disorder, also known as Pyroluria or Pyrroles, is a metabolic disorder that most commonly manifests as a mental health condition. Read on now.
What is Pyrrole Disorder? Pyrrole disorder, also known as pyroluria, kryptopyroluria, kryptopyrole or Mauve disorder is a biochemical imbalance involving an abnormality synthesis and metabolism of haemoglobin. It can be purely genetic, or acquired through environmental and emotional stress
What is Pyrrole Disorder? Pyrrole disorder, also known as pyroluria, kryptopyroluria, kryptopyrole or Mauve disorder is a biochemical imbalance involving an abnormality synthesis and metabolism of haemoglobin. It can be purely genetic, or acquired through environmental and emotional stress
The one-stop resource for your health related needs
Triggers of Adrenal Fatigue can mimic those of Pyroluria, including unhealthy lifestyle habits and poor diet. Learn how to differentiate the two.
Pyroluria is something we regularly test for and a valuable marker of our clients' metabolic, gut and mental health. Read on to learn more.
Have you ever heard of Pyroluria, Pyrroles, Mauve Factor, or Kryptopyrrole? I'll take a guess that for most of you, that's a 'no'. However, if mental health struggles plague you, you may want to keep reading about Pyrroles, a disorder not recognized by Western Medicine. Pyrroles can be genetic in nature as well as brought...Read More
Pyroluria, also called Malvaria, is a unique metabolic condition that is very rarely recognized in both the medical and natural health world.
Objective: The term “Mauve factor” (pyrroluria) dates back to 1958 when Dr. Abram Hoffer defined the condition as elevated levels of pyrroles in the urine, currently called hydroxyhemepyrrolin-2-one (HPL). It was suggested that the raised pyrrole levels lead to depletions in zinc and vitamin B6, which, in turn, were hypothesized to result in a range of psychiatric disorders, such as schizophrenia, anxiety, and depression. Treatment implications are supplementation with zinc and B6. This article aimed to review the scientific literature associating pyrroluria with psychiatric symptoms, explore the validity of HPL testing, explore the role of nutrients as treatment options for pyrroluria, and discuss future research directions. Methods: A PRISMA review was conducted using search results from electronic databases PubMed, MEDLINE, PsycINFO, EMBASE from inception to February 2020 using the following keywords: hydroxyhemepyryrrolin (HPL), kryptopyrrole (KP), mauve factor, pyroluria, pyrroluria, monopyrroles. Article reference lists were also scanned and included where relevant. Results: Seventy-three articles were identified of which only three studies identified significantly higher HPL levels in a psychiatric population compared with controls, and there were no placebo-controlled treatment trials directed at pyrroluria. The other 13 clinical studies either showed no association or did not provide adequate data to show group differences in HPL levels. Despite an extensive history of practitioners diagnosing and treating a wide variety of mental health conditions associated with pyrroluria as well as clinical observations of elevated HPL being associated with psychiatric disorders, there was no clear research that showed the following: (1) elevated HPL is robustly associated with increased mental health symptoms, (2) elevated HPL in urine is associated with increased urine excretion of zinc and B6, and (3) high-dose zinc and B6 are an efficacious treatment for mental health problems associated with elevated HPL. Conclusions: Elevated HPL is a clinically observed, but poorly researched biomarker with unclear associations with mental disorders. Based on current evidence, HPL testing is not recommended as a screening or treatment tool. Further research is required in the following areas: establishment of which specific clinical populations exhibit elevated HPL, validation of the chemistry and validity of testing, and controlled trials to establish efficacy of high-dose zinc and B6 as treatment of elevated pyrroles.
Omega 3 fatty acids increase inflammation for individuals with Pyrrole disorder. Click to read more and see which foods to avoid when you have Pyrrole disorder.
Here are my antianxiety amino acid and pyroluria supplement recommendations. These are the products I use with my one-one clients and those doing my online group programs.
What is Pyrrole Disorder? Pyrrole disorder, also known as pyroluria, kryptopyroluria, kryptopyrole or Mauve disorder is a biochemical imbalance involving an abnormality synthesis and metabolism of haemoglobin. It can be purely genetic, or acquired through environmental and emotional stress
What is Pyrrole Disorder? Pyrrole disorder, also known as pyroluria, kryptopyroluria, kryptopyrole or Mauve disorder is a biochemical imbalance involving an abnormality synthesis and metabolism of haemoglobin. It can be purely genetic, or acquired through environmental and emotional stress
Author: Michael McEvoy Pyroluria is a condition that has been known for several decades. It is sometimes referred to as mauve factor, KPU, kryptopyroluria and Hydroxyhemopyrrolin-2-one, or HPL. Besides acting as a tongue twister, this condition is potentially very serious, and may have numerous biochemical implications. Pyrroles are synthesized during hemoglobin production in the
Pyroluria is known by many different names including Pyrrole Disorder, Kryptopyrrole, Kryptopyrroluria, Pyrroluria, Mauve Factor and Hemepyrrole. As many as 50% of those with autism, 40% of alcoholics, 70% of schizophrenics, 70% of persons with depression and 30% of persons struggling with ADD may have pyroluria underlying their conditions. There are lifelong symptoms associated with it that tend to worsen with age and stress. During the synthesis of hemoglobin in the body, waste products called kryptopyrroles are generated. Kryptopyrroles are normally excreted uneventfully. In those with pyroluria, kryptopyrroles bind very strongly to zinc, vitamin B6, and Omega 6. This especially occurs when the individual encounters any sort of bodily stress, whether it be an illness, over-exertion, or mental/emotional stress. The kryptopyrroles are then excreted in the urine, taking these 3 important nutrients with them, which is a very big problem. These nutrients are critical for the functioning of your entire body and mind, including your digestion, immune system, cognitive functioning and emotions. Symptoms of pyroluria may lead to lifelong issues with severe inner tension, ongoing anxiety, poor stress tolerance (stress of any kind makes symptoms worse), digestive issues including digestion of meat, frequent colds and infections, joint pain or stiffness, acne, eczema or psoriasis, mood swings and reactivity. The really good news is that once diagnosed, pyroluria is very manageable. The bad news is that ongoing supplementation is needed indefinitely in order for symptoms to remain manageable long term. Without appropriate supplementation symptoms tend to return again in a week or two. Disorders commonly diagnosed in Pyrolurics: Alcoholism ADD/ADHD Autism/Aspergers Allergies Bi-Polar Disorder Down Syndrome Epilepsy Hypothyroidism Learning Difficulties (ie Dyslexia) Lyme Disease Manic Depression Muscular Sclerosis Neurosis/Neurotic - can become violent offenders Obsessive Compulsive Disorder (OCD) Parkinson's Disease Polycystic Ovarian Syndrome Post Partum Depression Rheumatoid Arthritis Schizophrenia Substance Abuse Tourette's Syndrome (Tics) Unfortunately Pyroluria falls outside the realm of mainstream medicine due to the fact that the only way to rectify the problem is by improving nutritional status, diet, digestion and stress levels. Mainstream medicine relies on drugs to suppress a symptom or relieve suffering, and this form of treatment will not work for a person who has a Pyrrole disorder. Sadly sufferers of Pyroluria fall through the cracks and are often misdiagnosed and given medication or drugs that do nothing to rectify the underlying problem. Unfortunately these medications can lead to further deterioration of a persons health. People with this disorder have copper toxicity. Copper is an essential trace mineral that is vitally important for both physical and mental health, as long as it is kept in proper balance. Zinc lowers copper in the body. Without it, copper builds up and depletes vitamin C, which results in frequent illness. Thyroid and Adrenal glands are extremely sensitive to copper. Copper toxicity leads to reduced thyroid function (hypothyroidism), which can be diagnosed as Hashimoto's. Copper Toxicity leads to headaches/migraines, fatigue, insomnia, depression, bipolar disorder, skin rashes, spaciness, detachment, learning disorders, PMS, memory loss, hair loss (especially among women), osteoporosis and addiction. It also leads to the rise of estrogen, which in large amounts, is a potent carcinogen and can cause cancer. Copper has a huge impact on children. High-copper mothers pass on excessive copper (and often low zinc) to the fetus through the placenta. It is also passed through breast milk, which can cause a baby to stop nursing prematurely. Common conditions such as ear infections, skin rashes and dandruff usually involve an imbalance between copper and zinc in children. Other conditions include learning and developmental disorders, colic, ADD/ADHD, sleep problems and childhood cancers. There are positive traits of high levels of copper, which include a warm, caring, sensitive, emotional nature and a child-like quality. Many traditionally feminine traits are associated with high copper levels, such as softness, gentleness and intuitiveness. High copper people are often young looking. But, if copper gets too high, negative personality traits show up. These include spaciness, poor memory, racing thoughts, living in a dream world, childishness, excessive emotions, sentimentality, tendency to depression, fearfulness, hidden anger/resentment, phobias, psychosis and even violence. Some with high copper dislike protein. They become obligatory vegetarians and crave high carbohydrate diets. This is because too much copper impairs liver function, which is necessary to break down protein. They are no longer able to digest meat very well. Protein feels heavy or causes other symptoms. However, these individuals usually NEED to eat protein because red meat is the best dietary source for zinc, which lowers the levels of copper, and makes the digestive enzymes needed for the breakdown of protein. In fact, becoming vegetarian actually makes things worse because vegetarian proteins are high in copper, such as nuts, beans, seeds and grains. Some may feel that they are becoming more "spiritual" on a vegetarian diet, but that goes along with the heightened emotional aspects of copper toxicity noted above. Once zinc is introduced, the taste for meat will come back, as will the ability to digest it. Vitamin B6 is essential for dopamine production, which is an essential neurotransmitter in the brain. When the body of a pyroluric individual is stressed, Vitamin B6 is excreted, thus the loss of dopamine. Dopamine has been called the "pleasure neurotransmitter." The body may crave sweets/carbs as a biologial attempt to increase dopamine, thus increase pleasure. Unfortunately, Zinc is also dumped in this process, which is essential to blood sugar regulation by influencing carbohydrate metabolism, increasing insulin response, and improving glucose tolerance. There is a clinical correlation between low zinc levels and insulin resistance. Insulin resistance is correlated with obesity and body fat distribution. Incidently, zinc deficiency is also related to the overgrowth of candida (yeast). Zinc deficient individuals may experience frequent yeast infections. They may also have a yeast overgrowth in the gut, which results in further cravings for sugar/carbs, as yeast feed and grow on these things. Below is a list of symptoms associated with Pyroluria. If you experience 15 or more of these, it is likely that you have Pyroluria. 1. Little or no dream recall (B6) 2. White spots on finger nails (Zinc) 3. Poor morning appetite +/- tendency to skip breakfast (Zinc) 4. Morning nausea (B6) 5. Pale skin +/- poor tanning +/- burn easy in sun 6. Sensitivity to bright light (Zinc) 7. Hypersensitive to loud noises (Zinc) 8. Sensitivity to smells (Zinc) 9. Poor ability to cope with stress (Zinc and B6) 10. Mood swings or temper outbursts (Zinc) 11. Histrionic (dramatic, emotional) tendency (Zinc) 12. Argumentative/enjoy argument (Zinc) 13. New situations or changes in routine are particularly stressful (B6) 14. Much higher capability and alertness in the evening, compared to mornings (Zinc) 15. Poor memory (Zinc and B6) 16. Obesity or Abnormal body fat distribution (Zinc) 17. Belong to a family with a lot of look-alike sisters 18. Dry skin (B6) 19. Anxiousness or nervousness, fearful, lifelong inner tension (B6) 20. Reaching puberty later than normal - growth after the age of 16 (Zinc) 21. Difficulty digesting, a dislike of protein or a history of vegetarianism (Zinc) 22. Tendency toward being a loner and/or avoiding larger groups of people 23. Stretch marks on skin (Zinc) 24. Poor sense of smell or taste; preference for spicy foods (Zinc) 25. Feel very uncomfortable with strangers 26. Frequently experience fatigue or exhaustion (Zinc) 27. A tendency to overreact to tranquilizers, barbiturates, alcohol or other drugs (in other words, a little produces a powerful response) 28. A tendency toward anemia 29. History of mental illness or alcoholism in family (Zinc and B6) 30. Easily upset by criticism, offended easily 31. Bad breath or body odor when ill or stressed (Zinc) 32. Prone to acne, eczema or psoriasis (Zinc) 33. Thin skin 34. Hyper-pigmentation of the skin 35. Bouts of depression or nervous exhaustion (B6) 36. Prone to frequent colds or infections (Zinc) 37. Abdominal pain; constipation, irritable bowel syndrome (Zinc) 38. Hair loss (lack of hair on head, eyebrows and/or eyelashes) (Zinc) 39. Irregular menstrual cycles, PMS (B6) 40. Low libido 41. Allergies (Zinc) 42. Tingling in arms and legs (neuropathy) (B6) 43. Migraines (B6) 44. Muscle pain (achey, flu-like tenderness) (B6) 45. Frequent yeast infections/yeast overgrowth (Zinc) 46. Reading difficulties (e.g. dyslexia) 47. Get motion sickness (B6) 48. Cold hands and feet (Zinc) 49. Codependency 49. Substance abuse/addiction (B6) 50. Creaking joints, joint pain, knee pain (B6) 51. Overcrowding of teeth in upper jaw (Zinc) 52. Poor looking tooth enamel; tendency for cavities (Zinc) 53. Delusions, hallucinations, paranoia (Zinc) 54. Emotionally unstable (Zinc) 55. Pessimism (Zinc) 56. Early greying of hair (Zinc) 57. Insomnia (Zinc and B6) 58. Prone to stitch in side when running (Zinc) 59. Hyperactivity (Zinc and B6) 60. Fluid retention (B6) 61. Obsessive Compulsive Disorder, which includes collecting/hoarding (B6) 62. Seizures (B6) 63. Hypoglycemia (Zinc) 64. Frequent ear infections as a child (Zinc) 65. Suicidal tendencies (Zinc) 66. Gluten intolerance (Zinc) 67. Prone to ovarian cysts (Zinc and B6) 68. Craving for sweets/carbs (Zinc and B6) 69. Tremors (B6) 70. Age related Macular Degeneration (Zinc) 71. Low Progesterone = miscarriage in first 7 weeks or early menopause (B6) As noted, if you experience a combination of the symptoms above, you likely have pyroluria. This can be tested through a simple urine test, however testing your levels of B6 (urine) and zinc (blood) are much more important. Copper levels can be tested in various ways, but requires more detail. Pyrolurics have a greater than normal need for zinc, vitamin B6 and omega-6 fatty acids. These can be supplemented individually or incorporated into the diet. The favoured forms of these nutrients are Zinc picolinate and Pyridoxal-5-phosphate (P5P) for B6. Vitamin B6 (P5P) is water soluble and is not stored in the body, so it's depleted rather quickly. It may be best to supplement this every few hours. B6 requires magnesium to be effective, so one must also ensure intake of magnesium. The standard american diet is full of omega-6 fatty acids due to over-use of cooking oils, so it's often not necessary to supplement this. The body does need dietary arachidonic acid (found in eggs, butter, red meat and liver) and the essential fatty acid GLA (found in supplements like black currant seed oil and evening primrose oil). Here is a great link with information on the importance of zinc, types of zinc to take, suggested dosage, and side effects of over-consumption, which is rare. Foods high in zinc, from highest to lowest: 1. Seafood: Oysters, crab and lobster 2. Beef and Lamb 3. Wheat Germ 4. Spinach 5. Pumpkin and squash seeds (also sunflower chia and flax) 6. Cashews (also pine nuts, pecans, almonds, walnuts, peanuts, hazelnuts) 7. Cocoa and chocolate (also high in copper) 8. Pork & Chicken 9. Mung beans (also baked beans, kidney beans, chickpeas) 10. White mushrooms (also Portabella and shitake) The safe upper limits for zinc are listed below. Life Stage Upper Safe Limit Birth to 6 months 4 mg Infants 7–12 months 5 mg Children 1–3 years 7 mg Children 4–8 years 12 mg Children 9–13 years 23 mg Teens 14–18 years 34 mg Adults 40 mg Zinc combined with certain foods may not be absorbed into your body, so it is important to avoid the following foods for at least 2 hours after you take zinc: Bran, Fiber-containing foods, Phosphorus-containing foods such as milk or poultry, Whole-grain breads and cereals. Zinc, Magnesium and Calcium compete for absorption, so it is best to take them separately to ensure you are getting the most out of your supplements. Unlike other trace elements zinc does not get stored in the body. For every 15mg of zinc you need to take 1mg of COPPER to maintain the correct balance. Here is a great link with information on the importance of B6, suggested dosage and side effect of over-consumption. Foods high in B6, from highest to lowest 1. Rice bran, brown rice 2. Chili Powder, paprika, garlic and other herbs/spices 3. Pistachios 4. Garlic (especially raw) 5. Liver 6. Yellow-fin Tuna, salmon, cod 7. Sunflower and sesame seeds 8. Pork tenderloin 9. Molasses and sorghum syrup 10. Hazelnuts The safe upper limits for vitamin B6 are listed below. Life Stage Upper Safe Limit Birth to 12 months Not established Children 1–3 years 30 mg Children 4–8 years 40 mg Children 9–13 years 60 mg Teens 14–18 years 80 mg Adults 100 mg Here is some more information, which includes testing and treatment. Here is another great site for information Testing can be done inexpensively, without a doctor, at the following labs: $80 - Direct HealthCare Access $79 - RiordanClinic In related news, Vitamin B6 (P5P) is becoming very controversial as the drug company, Medicure Pharma Inc, is petitioning to have the substance banned from OTC sale. The company plans to market it in their form of a vitamin/drug (named MC-1) after recent research is finding that it is effective in reducing injury associated with Ischemia. It has also been shown to reduce the risk of colon cancer. http://www.ncbi.nlm.nih.gov/pubmed/12020872 http://www.ncbi.nlm.nih.gov/pubmed/23467420 All this means is that we will no longer be able to buy P5P over the counter. Instead, we will have to get a prescription for it and pay a higher price to the pharmaceutical companies. References: http://www.ncbi.nlm.nih.gov/pubmed/18062169 http://jn.nutrition.org/content/133/5/1473S.long http://www.ncbi.nlm.nih.gov/pubmed/20097602 http://www.ncbi.nlm.nih.gov/pubmed/2761676 http://www.ncbi.nlm.nih.gov/pubmed/18383989 http://www.ncbi.nlm.nih.gov/pubmed/9659710?dopt=Abstract http://www.mothernature.com/Library/Bookshelf/Books/10/116.cfm http://www.mothernature.com/Library/Bookshelf/Books/10/116.cfm http://www.riordanclinic.org/research/articles/89024739.pdf http://www.biobalance.org.au/_downloads/discerning-the-mauve-factor-part-ii-galley.pdf The Relationship Between an Unknown Factor (US) in the Urine of Subjects and HOD Test Results. J Neuropsychiatry 2:363-368, 1961. (by Abram Hoffer MD, PhD & Humphry Osmond, M.D.) The Presence of Unidentified Substances in the Urine of Psychiatric Patients 2:331-362, 1961 (by Abram Hoffer M.D, PhD, et al) The Presence of Malvaria in Some Mentally Retarded Children. Amer J Ment Def 67:730-732, 1963. (by Abram Hoffer M.D, PhD, et al) Malvaria: A New Psychiatric Disease. Acta Psychiat Scand 39:335-366, 1963. (by Abram Hoffer MD, PhD & Humphry Osmond, M.D.) Malvaria and the Law. Psychoso-matics, 7:303-310, 1966. (by Abram Hoffer M.D, PhD, et al) Mauve spot and schizophrenia. American Journal of Psychiatry 125(6):849-851, 1968. Biochemical relationship between kryptopyrrole (mauve factor and trans-3-methyl-2-hexenoic acid schizophrenia odor). Res Commun Chem Pathol Pharmacol 1973 (by Carl Pfeiffer MD, PhD, et al.) Studies on the occurrence of the mauve factor in schizophrenia [article in Polish]. Psychiat. Pol., 7(2):153-9, 1973. Treatment of pyroluric schizophrenia (malvaria) with large doses of pyridoxine and a dietary supplement of zinc. J. Orthomolecular Psychiatry3(4):292 1974 (by Carl Pfeiffer PhD, MD & Arthur Sohler PhD) A rapid screening test for pyroluria; useful in distinguishing a schizophrenic subpopulation. J. Orthomolecular Psychiatry 1974 3(4):273 (by Arthur Sohler PhD) Neurological and behavioral toxicity of kryptopyrrole in the rat., Pharmacol Biochem Behav 3(2):243-50 1975 Ward, J.L., Relationship of Kryptopyrrole, Zinc and Pyridoxine in Schizophrenics,Journal of Orthomolecular Psychiatry, 1975. Irvine, D.G., Pyrroles in Neuropyschiatric and Porphyric disorders: confirmation of a metabolite structure by synthesis, Life Sci, 1978. Zinc and Manganese in the Schizophrenias. J. Orthomolecular Psychiatry 12(3):215 1983 (by Carl Pfeiffer PhD, MD and Scott LaMola, BS) A new prostaglandin disturbance syndrome in schizophrenia: delta-6-pyroluria., Med Hypotheses 19(4):333-8 1986 Pfeiffer, C.C. and Holford, P., Mental Illness and Schizophrenia: the Nutritional Connection, Harper Collins, 1987. Pyroluria – Zinc and B6 deficiencies. Int Clin Nutr Rev 1988 (by Carl Pfeiffer MD, PhD, et al.) Pfeiffer, C.C., Mailloux, R., and Forsythe, L., The Schizophrenias: ours to conquer, Biocommunications Press, 1988. Cutler, M.G., Graham, D.J., and Moore, M.R., The Mauve Factor of Porphyria, 3-ethyl-5-hydroxy-4,5-dimethyl-delta-3-pyrrolline-2-one: effects on behaviour of rats and mice,Pharmacology & Toxicology, 1990. The Discovery of Kryptopyrrole and its Importance in Diagnosis of Biochemical Imbalances in Schizophrenia and in Criminal Behavior J. Orthomolecular Medicine 10(1):3 1995 (by Abram Hoffer M.D, PhD) Fatty Acid Profiles of Schizophrenic Phenotypes, 91st AOCS Annual Meeting and Expo San Diego, California 2000 (by William Walsh PhD of the Pfeiffer Treatment Center) Urinary Pyrrole (Mauve Factor): Metric for Oxidative Stress in Behavioral Disorders, presented to the Linus Pauling Institute, 2003 (by Woody R. McGinnis MD) Campbell-McBride.N., Gut and Psychology Syndrome, Medinform Publushing, 2004. Forsgren.S., 2010, Kryptopyrroluria (aka hemopyrrollactamuria): A major piece of the puzzle in overcoming Lyme disease, Public Health Alert, vol. 5, no. 5, viewed 23rd January 2011. http://www.publichealthalert.org/Articles/scottforsgren/2Klinghardt.htm McGinnis, W.R., 2004, Pyroluria - Hidden Cause of Schizophrenia, Bipolar, Depression and Anxiety Symptoms, International Guide to the World of Alternative Health, viewed 24th January 2011.http://www.alternativementalhealth.com/articles/pyroluria.htm Grundy SM. Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 1999;83:25F-29F. Chen MD, Lin PY, Lin WH. Investigation of the relationships between zinc and obesity. Kao Hsiung I Hsueh Ko Hsueh Tsa Chih 1991;7:628-634. [Article in Japanese] http://www.drugs.com/cons/zinc-supplement-oral-parenteral.html
Many people suffering from Pyroluria also endure the crippling effects of Depression, without fully understanding why. I hope that by the end of this podcast the link between Depression and Pyroluria will become a lot clearer.
Triggers of Adrenal Fatigue can mimic those of Pyroluria, including unhealthy lifestyle habits and poor diet. Learn how to differentiate the two.
Pyrrole Disorder, also known as Pyroluria or Pyrroles, is a metabolic disorder that most commonly manifests as a mental health condition. Read on now.
This questionnaire will help you identify whether you might have pyroluria, a social anxiety condition. The physical and emotional symptoms below are caused by deficiencies of vitamin B6 and zinc. When you experience high levels of stress, vitamin B6 and zinc will be further depleted, so you may notice worsening symptoms and more anxiety. Based …
Here are my antianxiety amino acid and pyroluria supplement recommendations. These are the products I use with my one-one clients and those doing my online group programs.
Pyrrole disorder is a stress disorder that can be seen in anyone of any age. Mood instability can be caused by pyrrole disorder, which is becoming more
Low levels of the mineral zinc and vitamin B6 are frequently associated with a type of anxiety characterized by social anxiety, avoidance of crowds, a feeling of inner tension, and bouts of depression. People with this problem experience varying degrees of anxiety or fear, often starting in childhood, but they usually manage to cover it […]
A detailed description of the blood disorder Pyroluria, a condition that creates a major deficiency in Vitamin B6 and Zinc. Also discussed are associated conditions and treatment options.
