After 7 years of research here is how I reset my hormones, healed my thyroid, and lost over 50 pounds and have kept it off!
One of the top questions I get asked is what I recommend to help the body fix itself, at a foundational level. Perhaps you are craving this knowledge, and want nothing…
If you've ever struggled to lose weight and/or keep it off, you probably have one of these 4 hormonal imbalances. Find out more...
Best hormone balancing foods to eat if you want to naturally correct imbalances. Balance hormonal acne naturally.
Today's post will cover how Fasting can help our metabolic fitness overall and rebalance our hormones naturally.
Discover the transformative power of The Flat Belly Fix program. Achieve your weight loss goals with exercise, nutrition guidance, and mindset strategies. Acces
One of the top questions I get asked is what I recommend to help the body fix itself, at a foundational level. Perhaps you want nothing more than to return to a state of wholeness and zen-like hormone balance. Maybe you feel frustrated and desperate. Maybe you’ve worked with other doctors, only to be given […]
Discover the key signs of hormonal imbalance symptoms in females. Dive deep into causes, remedies, and ways to restore hormonal harmony in women
Discover which hormones change your weight and how to control them.
THIS IS NOTE IS LARGE AND HAS LOTS OF PICTURES; MOST PICS ARE TAKEN FROM SILVERTHORN TEXTBOOK What are the different types of hormones? How are hormones released and controlled? What are the major endocrine organs (glands) and endocrine pathogenesis as well as the interactions between hormones (synergistic or antagonistic) What are hormones? Hormones: derived from greek verb ormao = 'to excite or arouse', they are chemical messengers secreted into the blood by specialised cells and generally act on remote organ sites and alter rates of processes in target cells. They act at very low concnetrations nano to picomolar range (10^-9 to 10^-12). They control long-term homeostatic processes: Grow, development, metabolism, reproduction and internal environment regulation. Hormones are produced by endocrine cells and organs - released from endocrine glands. Endocrinology is the study of the endocrine system and hormone action Hormones act by binding receptors on or in target cells: - Controlling the rates of enzymatic reactions. - Controlling the movement of ions or molecules across membranes - Controlling gene expression and protein synthesis Hormones have half-lives; i.e. they act for specific period of time before becoming inactivated. Abit of history of endocrinology: First experiments performed in mid 1800s. 1849 Berthold and his roosters. 1889 C. Brown-Sequard's Viagra. 1889 discovery of insulin by Minkowski. 1891 thyroid hormone replacement. 1922 purified insulin was used in clinical trials Types of Hormones Many different classification schemes: a. Protein/peptide b. Steroid (cholesterol derivatives) c. Amine (tryptophan or tyrosine derivatives) OR i. Lipophilic: penetrate cell membrane readily (steroid hormones and thyroid hormones) ii. Lipophobic: do not penetrate cell membrane (peptides and catecholamines) Look at the figure to the right to see the different hormones - must know ALL (espcially the most important - thyroid, parathyroid, adrenal, pancreas, hypothalamus-pituitary, gonads) A. PROTEIN AND PEPTIDE HORMONES These are the most common types of hormones. - preprohormone - large inactive - prohormone - posttranslational modification - peptide hormone-receptor complex - signal transduction system Stored in secretory vesicles and secreted by exocytosis. Dissolved in blood for transport. Act on cell surface receptors - do not penetrate target cell by diffusion. Rapid onset, short duration and short half-life in the blood - usually inactivated by proteases. Not active orally. This is because they are proteins/peptides and are digested in the gut (so administration is other than oral cavity - injections!?) More is discussed below about hormone receptors B. STEROID HORMONES - Cholesterol-derived synthesized in the smooth ER. Synthesize as needed from precursors. Lipophilic and can diffuse across membranes and are not stored in secretory cell. They transported through the blood with carrier proteins. They bind on intracellular receptor (cytoplasmic or nuclear receptors (mostly)) which recognize specific steroids. Steroid hormones induce their effects by altering transcription - they activate or repress gene expression for protein synthesis. They are slower acting and have long duration and longer half-life. May be active orally Examples: cortisol, estrogen, testosterone The pineal gland, the thalamus and corpus callosum HORMONE RECEPTORS (some things are mentioned below again; this area must be cleaned!) Hormones work by binding to specific receptors on or in target cells. Receptors are specific for hormone(s). Presence of receptor is necessary for response in cell. Cells have multiple receptors for different hormones. Some hormones have more than one type of receptor; e.g. multiple types adrenergic receptor. They can get up or down regulation of receptors. Little exposure to hormone - upregulation; e.g. alloxan diabetes. Lot of exposure to a hormone - down regulation - type 2 diabetes? Agonists: substances that bind to receptor and mimic effect of a hormone. Antagonists are substances that bind to receptor but do not stimulate, so block the effect of a natural hormone. Partial agonists bind and havve low activity, phytoestrogens in soya. Many drugs act as hormone agonists/antagonists Types of hormone receptors 1. Intracellular receptors that affect mRNA transcription 2. G-protein coupled receptors 3. Tyrosine Kinase associated receptors (RTK) 1. Intracellular receptors Lipophilic hormone enters cell by simple diffusion. It binds to receptor in nucleus or cytoplasm (translocated to nucleus). Binding induces conformational change and form receptor dimers. The activated receptor has a DNA binding region that binds to ''hormone-responsive elements'' of DNA. Receptor binds to specific base sequences on DNA so affects specific genes. Binding of receptor to DNA switches genes for proteins in that area on or off. Get induction or repression of synthesis of key proteins. Calcitriol (from vitamin D) induces synthesis of several key proteins involved in calcium transport in the gut. 2. G-protein coupled receptors - GPCR Proteins in membrane with three subunits α,β and γ. They are called G proteins because they are associated with GDP/GTP. G protein complex in membrane with GDP bound to a region. Hormone binds to GPCR increases its affinity for αβγ-trimer. When GPCR and αβγ unit combine, the GDP on the α unit is replaced by GTP. The α unit when bound to GTP dissociates from βγ. The α unit binds to a membrane enzyme (or ion channel) and alters its activity. The α unit is a weak GTPase and as GTP is converted to GDP so it rebinds to form αβγ - so terminating its effects. G-proteins There are several types of G-proteins. Proteins Gs and Gi stimulate or inhibit the membrane enzyme adenylate cyclase. This catalyses ATP to cyclic AMP which is a secondary messenger which brings about intracellular hormone effects. There are other second messengers like cGMP, inositol triphosphate, diacyglycerol and calcium. Sorry for the informal diagram! Glucagon and cAMP Glucagon binds to its membrane receptor. The αβγ G protein attaches to the receptor. The α unit's GDP is replaced by GTP; this α unit detaches and binds to and activates membrane adenylate cyclase. Increased cAMP produced inside the cell. α-unit converts GTP to GDP and it rejoins to βγ-unit - cessation of effect. Cyclic AMP binds to and activates cAMP dependent protein kinase (PKA). This protein kinase adds phosphate residues to specific protein sites which activate or inhibit it. Glycogen synthase becomes inactive when phosphorylated - less glycogen synthesis. PKA phosphorylates phosphorylase kinase to make it more active and this in turn phoshorylate phosphorylate b (inactive) to an (active) increased glycogen breakdown. cAMP broken down to AMP by enzyme phosphodiesterase which stops effect. Phosphodiesterase inhibited by caffeine, theophylline and sidenafil (viagra - omg). Phosphatases within cell remove phosphate groups from protein - counteract protein kinases. Enzyme activity depends upon proportion phosphorylated - balance of kinase and phosphatase effects! cAMP A number of hormones work via cAMP as a secondary messenger. Precise effect of rise or fall in cAMP depends upon tissue enzymes. Catabolic enzymes are more active when phosphorylated i.e. by increased cAMP - anabolic less active. Theophylline potentiates effects of cAMP and is a derivative of cAMP that penetrates cell and mimics effect of cAMP (hormone?) Phosphotidyl inositol system When hormone binds to its receptor it activates a G-protein. The α subunit binds to and activates phospholipase C in membrane. This enzyme converts phospholipid phosphotidyl inositol biphosphate (PIP2) to diacylglycerol (DAG) and inositol triphosphate (IP3) - both are secondary messengers. Diacylglycerol (DAG) This activates protein kinase C in the membrane. This causes protein phosphorylation which brings about a response in the cell. Inositol Triphosphate (IP3) Enters cytoplasm. Triggers calcium release from endoplasmic reticulum. This calcium binds to a protein called calmodulin which activates a calmodulin sensitive protein kinase. Calcium can also trigger secretion. Guanylate cyclase The receptor(s) for atrial natriuretic factor (ANF) have a guanylate cyclase component. The ANF binds to the receptor which increases guanylate cyclase activity. Cyclic GMP is produced in the cell - the secondary messenger. 3. Tyrosine Kinase associated receptors (RTK) Insulin and receptor tyrosine kinase (RTK) Insulin receptor is tetramer α2β2. Insulin binds to external binding sites on a subunits. The β subunits are large transmembrane proteins with tyrosine kinase activity. The α units suppress the TK activity but when insulin binds this removes inhibition. The TK units phosphorylate each other and other cellular proteins. TK effects: activates a protein phosphatase which dephosphorylates glycogen synthase - activated. In cells like muscle and fat releases the glucose transporter GLUT-4 from vesicles to membrane. Other effects also... The hormone receptor complexes aggregate and internalised into vesicles and insulin is degraded. Feedback loop and Response loop Now lets talk abit about the how hormones are controlled Afferent: incoming signal: a. Stimulus -> b. Sensor or Receptor -> -> d. Afferent Pathway -> Efferent: outgoing signal: -> e. Integrated center -> f. Efferent pathway -> g. Target or Effector -> h. Response (this was the response loop: from stimulus to response) (Feedback loop: from response back to stimulus is the feedback loop mechanism)......Stimulus -> Sensor or receptor......etc. We gone see how this control mechanism (stimulus then sensor or receptor then afferent pathway to integrated center to efferent pathway then target or effector and response) occurs in other hormones and in different examples. Look (click) at the diagrams!!! Example 1 Example 2 Major endocrine organs Brain: - Hypothalamus (trophic and neurohormones) - Pituitary Gland (8 major hormones) Other organ sites: - Thyroid gland (thyroid hormones and calcitonin) - Adrenal cortex: cortisol and other steroids - Adrenal medulla: catecholamines - Liver: IGFs - Pancreas: insulin and glucagon - Gonads: sex hormones Neurohormone is any hormone synthesized and released by a neuron Trophic hormone is a hormone that controls the secretion of another hormone. Posterior Pituitary Summary of hormones Endocrine Control Three levels: Hypothalamic stimulation >> Hormones are synergistic and antagonistic such as the antagonism between insulin and glucagon, thyroid and parathyroid, etc.. The diagram below shows the antagonisms of hormones. Proper balance between them is extremely important for health Summary: Hormones are chemical messengers. They are synthesized, released and act at remote sites. Three main groups of hormones (proteins/peptides, steroids, amines). Each group has a different mechanism of action. Hormone release and action is controlled by response feedback loops; these loops can have multiple input and output points. Each endocrine organ makes a specific set of hormones. Hypothalamus and Pituitary gland (hormone central). Steroid hormone synthesis mainly in adrenal gland. Endocrine disorders from hormone imbalances also occur producing hyper/hypo secretion. Like the thyroid gland hyper/hypo, growth hormone production and the pancreas and insulin/glucagon balance. Also remember the importance of hormone synergy and antagonism (look at the hormone wheel diagram!) -------------------------------------------------------------------------------------------------------------- Now lets talk abit about glucose and calcium metabolism problems Insulin and Diabetes: An overview Table of Contents: History and discovery of insulin Nature of insulin and implications Actions of insulin Control of insulin secretion Glucagon actions Control of glucagon release Integrated pancreatic control of blood glucose Diabetes mellitus and its types Symptoms and long term complications Causes Pathophysiology Diagnosis Treatment Prevention Introduction - Islets of Langerhans in pancreas: α cells secrete glucagon β cells secrete insulin - Diabetes mellitus (lack of insulin) most common endocrine disorder - 1.8 million diabetics in UK (3%) 1.55 million type 2 and may be 1 million more undiagnosed (5% of NHS spending) - Pima Indians (Arizona) half population over 35 years diabetic - also very prevalent in South Asians in UK. Historical Landmarks - 150-200AD term Diabetes (syphon) applied to condition in which ''flesh and bones melt down into urine'' - 1674 the term Mellitus (honeyed) was applied because of urine's sweet taste - 1889 - Pancreatectomy in dogs produces diabetic-like state postulated that pancreas produces an antidiabetic factor. - Ligation of pancreatic duct causes degeneration of pancreas but not islets - no diabetes - 1909 the term insulin was coined but could not be isolated - 1921 Banting and Best extracted insulin from dog pancreas. - 1953 Sanger - complete sequence of insulin.1st protein to be sequenced Nature of Insulin - Protein hormone of 51 amino acids - not active by mouth. A chain is 21 aa and the B chain is 30 aa. Linkages are S-S links between cysteine residues. Pig and beef insulin are active in humans despite slight differences. First treatments were with impure animal insulin; now use ''monocomponent'' human insulin. - 1969: Proinsulin extracted from pancreas. Single chain of 84aa and C-peptide (33aa) cut out to leave insulin i.e. 1 gene. C-peptide used as a marker for endogenous insulin production in diabetes. Actions of Insulin - Increased synthesis glycogen, fat and protein. - Increased glucose uptake into muscle and adipose tissue but not brain, liver, red cells, etc. - Increased glycogen formation and glucose use - Increased fat synthesis - Increased protein synthesis in muscle - Reduced ketone production - So lack of insulin......... Control of insulin secretion Increases in blood glucose (and blood amino acids) have direct effect on β-cell. GIP produced by gut in response to eating increases insulin release - anticipatory. Parasympathetic stimulation (vagus) increases release but sympathetic reduces it. Glucagon 29 amino acid peptide from α-cells. Increases glycogen breakdown and gluconeogenesis in liver. Release is stimulated by low blood glucose. High blood amino acids increases release but this is suppressed by high blood glucose. Increases by sympathetic or parasympathetic activity, DIABETES Diagnosis - Symptoms plus casual plasma glucose 11.1mmol/l. - Fasting (8h+) plasma glucose 7.0mmol/l (6.1 for whole blood). - 2h plasma glucose 11.1mmol/l during oral glucose (75g) tolerance test. - 6.1-7mmol fasting impaired - half will become diabetic within 10yrs - No symptoms - need to repeat Type 1 diabetes Type 1 diabetes - Less than 10% of total - Characterized by β-cell destruction and almost total failure of insulin supply. Fairly rapid onset usually in childhood. Need isnulin injections and prone to ketoacidosis - Often thin at diagnosis. Inherited predisposition (linked to tissue-type) - environmental trigger(s) e.g. infection - Most have autoantibodies to β-cells at diagnosis Type 2 diabetes Type 2 Diabetes - No initial β-cell degeneration. Gradual onset traditionally in people over 40 but starting to occur in young - why? - Usually overweight at diagnosis - Symptoms relatively mild at start and ketoacidosis uncommon (undiagnosed) - Most do not need insulin unless advanced - Runs in families but not linked to tissue type and no islet cell antibodies present - Prevalence increasing as population ages and gets fatter Causes of type 2 diabetes: - No initial β-cell pathology and insulin still produced (absolute level may be high) - Reduced sensitivity to insulin - need more to get same effect - Genetic susceptibility - racial differences - Environmental triggers - ''western diet and lifestyle'' high fat diet; inactivity; overweight and abdominal obesity Metabolic syndrome (syndrome X) - Insulin resistance causes problems even without diabetes: high blood insulin, moderate hyperglycaemia, hypertension, raised blood TAg and lowered HDL. - Many later become diabetic and all at increased risk of CHD Diagnosis High waist (102cm men or 88cm women) or WHR 0.95/0.85 Moderate fasting hyperglycaemia Elevated BP Elevated TAG Low HDL ANY THREE suggests diagnosis Symptoms of Diabetes Mellitus Symptoms of diabetes mellitus High blood glucose (diagnosis) – why?? Glucose in urine – why?? Diuresis – why?? Prone to dehydration despite increased thirst and drinking In type 1 get ketoacidosis: Fatty acids →Acetyl CoA → Ketones Rapid weight loss (may also occur in type 2 so underestimate link with obesity) Hypoglycaemic coma? Long term complication Diabetics tend to die prematurely despite effective short term treatment Very high rates of cardiovascular disease – insulin resistance (pre-diabetes) is a risk factor for heart disease Also prone to retinopathy and cataracts – blindness Diabetic nephropathy (renal failure) Gangrene and risk of amputation Causes of long term problems High levels of blood lipoproteins causing increased risk of atherosclerosis in arteries Changes in functioning of small blood vessels due to persistent hyperglycaemia and glycosylation of protein in membranes Latter thought to be important factor in retinopathy and renal failure To improve long term prospects Normalise blood lipoprotein profile Normalise body weight Minimise the hyperglycaemia without repeated bouts of hypoglycaemia Diagnose and treat hidden cases because long term damage is ongoing Implementation Low (saturated) fat diet – prior to 1970 diabetic diet was high fat low carbohydrate. sSubstitution of complex for simple carbohydrates, increase in dietary fibre, restriction of energy intake (when necessary) This helps to normalise blood lipoproteins but also improves insulin sensitivity Rapid self monitoring of blood glucose Long term check – glycosylated haemoglobin Use of rapid soluble insulin and prolonged action depot insulin Oral hypoglycaemic agents Sulponylureas act to stimulate insulin release (e.g. tolbutamide and chlorpropamide) – only work in type 2 where there are functioning β-cells Biguanides – reduces hepatic gluconeogenesis, slows absorption from gut and increases uptake by muscle 2 Trials Diabetes Control and Complications Trial DCCT) for type 1 UK Prospective Diabetes Survey - type 2 Development renal, retinal & neuropathy delayed by intensified therapy Higher glycated Hb – more complications & deaths Calcium and Osteo Calcium Balance - Overview of typical calcium fluxes - Vitamin D – nature and role - Role of parathyroid hormone - Role of calcitonin - Integrated control of blood calcium - Osteoporosis - What is it? - What causes it? - What can be done about it? Calcium For adults: Gains – losses = 0 Growth & pregnancy – net gain Gains and losses hormonally controlled 99% of body calcium is in bone mineral as hydroxyapatite – c1kg Bone is a reserve of calcium – release or uptake of Ca2+ hormonally controlled Functions of non-bone calcium Muscle contraction – excitation triggers Ca2+ release which triggers contraction Hormone/transmitter release Intracellular regulator Co-enzyme function – blood clotting Etc So blood calcium finely regulated and must be kept within narrow limits Osteoporosis Thinning of bones making them susceptible to fracture e.g. from simple fall Up to 3 million people in UK may be affected – annual toll of: 70,000 hip fractures 40,000 recorded vertebral fractires 50,000 wrist fractures c20,000 death each year attributable to hip fractures Nature of osteoporosis Osteoclasts – breakdown of bone Osteoblasts – make new bone Bone constantly being remodelled but in later life synthesis slightly less than breakdown so gradual erosion Risk factors for osteoporosis Bone mass declines with age acceleration at menopause (more elderly women more osteoporosis) Inactivity – weight bearing exercise increases bone mass and inactivity leads to loss of bone Lack of sex hormones (even in men)– early menopause, anorexia etc Lack of vitamin D (sunlight exposure) What about calcium intake?? Smoking, heavy drinking, being underweight Osteoporosis – strategies for reducing its effects Increase peak bone mass – e.g. encourage activity in children and young adults Slow decline in bone mass – activity, vitamin D, HRT in older people also drugs that block bone breakdown Reduce risk of falling – building design and maintenance, maintain muscle strength, protect hips with padding? Increase bone strength – reverse process of oseoporosis Conventional treatments Oestrogen therapy – good preventative Vitamin D/calcium - 40% of old people in residential homes have biochemical evidence of vit. D deficiency Calcitonin as nasal spray or by injection – blocks bone breakdown Biphosphonates are analogues of pyrophosphate (etidronate and alendronate) adsorbed onto bone mineral and inhibit resorption Teriparatide – new treatment Active parathyroid analogue which is injected Leads to formation of strong new bone – reverses osteoporosis Treatment for up to 18 months and benefits last beyond this Theory: Pth leads to increased renal Ca2+ reabsorption, vit D activation and bone breakdown – but latter only at high doses At low doses Pth stimulates osteoblasts (bone makers) before osteoclasts (bone breakers) HRT HRT has been first line preventative for osteoporosis Endometrial cancer is a clear risk of oestrogen alone so must give with synthetic progestin if uterus present Conclusively show to reduce bone loss in postmenopausal women Case-control studies – up to 50% reduction in hip fractures in menopausal women taking oestrogen More problems with HRT Nelson et al (2002) – HRT increased risk of heart disease in elderly women Beral et al (2003) Million women study – HRT small increase in breast cancer risk 2003 MHRA advised GPs that HRT should not be used for long periods to prevent osteoporosis in women over 50 Phyto-oestrogens Are these an alternative to HRT? Substances from plants not steroids but have oestrogenic activity Isoflavins (genistein, daidzein) from soy and other legumes Lignans in whole grains Coumestins in clover and alfalfa sprouts Soy foods and supplements, blach cohosh, red clover 2-4 mg isoflavins per mg soy protein Supplements c40mg/day Some diets high in soy 100mg/day Babies soy formula 4mg/kg body weight Act as partial agonists so can increase or decrease oestrogenic activity depending upon circumstances c1:10,000 potency of oestrogen But HRT c50μg/day whereas supps 1000X more by weight of isoflavins So significant total activity Branca 2003 In vitro genistein reduces osteoclast activity but increases osteoblasts Soybean feeding increases bone density in ovariectomised rats Women in SE Asia (where soy intakes are high) – women with highest intakes have higher bone density Not seen where soy intakes are lower (need high dose) Review of 7 studies suggest phyto-oestrogens over 6 months positive influence on bone density in lumbar spine Phyto-oestrogens – substantial report published by Food Standards Agency Other benefits? Possible risks?
5 herbal Supplements to help you balance your hormones, naturally. These supplements help balance female hormones without over the counter meds.
Discover the Science Behind Hormonal Weight Loss and the Breakthrough 30-Second Fix That Transforms Bodies in Record Time In the constant pursuit of achieving our ideal weight, we often encounter numerous roadblocks that seem insurmountable. However, what if I told you that there's a revolutionary solution capable of addressing these barriers head-on? Welcome to the world of "The 5 Hormonal Blocks," a groundbreaking approach to weight loss that targets the root cause of your struggles. In this comprehensive review, we'll delve deep into the science behind hormonal weight loss and unveil the transformative power of the 30-Second Fix that has left countless individuals amazed by its efficacy. Introduction: Unravelling the Mystery of Hormonal Weight Loss Weight loss is not merely about counting calories or sweating it out at the gym; it's a complex interplay of biological factors that influence our body's ability to shed excess pounds. Among these factors, hormones play a pivotal role, regulating everything from metabolism to appetite control. However, when these hormones become imbalanced, they can create significant barriers to weight loss, making it seem like an impossible feat. Fortunately, "The 5 Hormonal Blocks" offers a beacon of hope for those struggling to lose weight despite their best efforts. Developed by experts in the field of endocrinology and nutrition, this revolutionary formula targets the five key hormonal imbalances that commonly thwart weight loss efforts. But what exactly are these hormonal blocks, and how does the 30-Second Fix come into play? Let's embark on a journey to uncover the answers. Understanding the Five Hormonal Blocks Insulin Resistance: One of the primary culprits behind stubborn weight gain, insulin resistance occurs when cells in the body become less responsive to the hormone insulin, leading to elevated blood sugar levels and increased fat storage. The result? Difficulty in shedding excess weight, particularly around the abdomen. Leptin Resistance: Often referred to as the "hunger hormone," leptin plays a crucial role in regulating appetite and energy expenditure. However, when the body develops resistance to leptin, it disrupts the signals responsible for signaling satiety, leading to overeating and weight gain. Cortisol Imbalance: As the body's primary stress hormone, cortisol plays a vital role in regulating metabolism and managing fat storage. However, chronic stress can lead to imbalances in cortisol levels, triggering excessive fat deposition, particularly in the abdominal region. Thyroid Dysfunction: The thyroid gland controls metabolism by producing hormones that regulate energy expenditure. When thyroid function is impaired, it can result in a sluggish metabolism, making it challenging to burn calories efficiently and leading to weight gain. Estrogen Dominance: In both men and women, estrogen plays a critical role in fat distribution and metabolism. However, an imbalance in estrogen levels, characterized by excess estrogen relative to progesterone, can contribute to weight gain, particularly around the hips and thighs. The 30-Second Fix: A Game-Changer in Hormonal Weight Loss Now that we've identified the five hormonal blocks standing in the way of your weight loss goals, it's time to unveil the secret weapon: the 30-Second Fix. This revolutionary technique targets the underlying hormonal imbalances with remarkable precision, offering a swift and sustainable solution to your weight loss woes. But what exactly does the 30-Second Fix entail? At its core, this technique involves a series of simple yet highly effective exercises designed to stimulate the body's natural hormone production and restore balance to key regulatory pathways. By dedicating just 30 seconds a day to these targeted movements, you can kickstart your metabolism, regulate appetite, and promote fat burning, all without the need for expensive supplements or restrictive diets. Real-Life Success Stories: Transformations That Inspire While the science behind "The 5 Hormonal Blocks" and the 30-Second Fix is undeniably compelling, the true testament to its effectiveness lies in the real-life success stories of individuals who have embraced this transformative approach to weight loss. From busy professionals to stay-at-home parents, people from all walks of life have experienced remarkable results, shedding pounds and inches in record time. Take Sarah, for example, a 35-year-old mother of two who had struggled with weight gain since her pregnancies. Despite countless fad diets and exercise regimens, she found herself trapped in a cycle of yo-yo dieting, unable to maintain any meaningful progress. However, after discovering "The 5 Hormonal Blocks" and implementing the 30-Second Fix into her daily routine, Sarah experienced a dramatic transformation. Within just one week, she noticed a significant reduction in cravings, increased energy levels, and a noticeable slimming of her waistline. Today, Sarah is healthier, happier, and more confident than ever before, thanks to the power of hormonal weight loss. Conclusion: Embracing a New Era of Weight Loss In a world inundated with quick-fix solutions and empty promises, "The 5 Hormonal Blocks" offers a refreshing alternative: a science-backed approach to weight loss that addresses the root cause of your struggles. By targeting hormonal imbalances with precision and offering a simple yet effective solution in the form of the 30-Second Fix, this revolutionary formula has the potential to transform not just your body, but your entire outlook on life. So why wait any longer to unlock the secrets of hormonal weight loss? 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I use the DUTCH test for hormones in my practice to help identify the root cause of hormone imbalances. Many of the women that I work with come to me feeling overwhelmed with trying to take care of family and work all while not feeling their best. They are dealing with many of the common symptoms of a hormone imbalance such as heavy/painful periods, PMS, headaches,
So many women ask me about hormone testing. They want to know which hormones they need to check and why and if they can do the hormone test at home.
Discover which hormones change your weight and how to control them.
A review of important hormones and foods that could be causing hormone imbalance. Includes a hormonal imbalance diet plan with free pdf.
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Think you may have a hormonal imbalance and want to naturally balance your hormones? Look no further, here's the answer you're looking for.
THIS IS NOTE IS LARGE AND HAS LOTS OF PICTURES; MOST PICS ARE TAKEN FROM SILVERTHORN TEXTBOOK What are the different types of hormones? How are hormones released and controlled? What are the major endocrine organs (glands) and endocrine pathogenesis as well as the interactions between hormones (synergistic or antagonistic) What are hormones? Hormones: derived from greek verb ormao = 'to excite or arouse', they are chemical messengers secreted into the blood by specialised cells and generally act on remote organ sites and alter rates of processes in target cells. They act at very low concnetrations nano to picomolar range (10^-9 to 10^-12). They control long-term homeostatic processes: Grow, development, metabolism, reproduction and internal environment regulation. Hormones are produced by endocrine cells and organs - released from endocrine glands. Endocrinology is the study of the endocrine system and hormone action Hormones act by binding receptors on or in target cells: - Controlling the rates of enzymatic reactions. - Controlling the movement of ions or molecules across membranes - Controlling gene expression and protein synthesis Hormones have half-lives; i.e. they act for specific period of time before becoming inactivated. Abit of history of endocrinology: First experiments performed in mid 1800s. 1849 Berthold and his roosters. 1889 C. Brown-Sequard's Viagra. 1889 discovery of insulin by Minkowski. 1891 thyroid hormone replacement. 1922 purified insulin was used in clinical trials Types of Hormones Many different classification schemes: a. Protein/peptide b. Steroid (cholesterol derivatives) c. Amine (tryptophan or tyrosine derivatives) OR i. Lipophilic: penetrate cell membrane readily (steroid hormones and thyroid hormones) ii. Lipophobic: do not penetrate cell membrane (peptides and catecholamines) Look at the figure to the right to see the different hormones - must know ALL (espcially the most important - thyroid, parathyroid, adrenal, pancreas, hypothalamus-pituitary, gonads) A. PROTEIN AND PEPTIDE HORMONES These are the most common types of hormones. - preprohormone - large inactive - prohormone - posttranslational modification - peptide hormone-receptor complex - signal transduction system Stored in secretory vesicles and secreted by exocytosis. Dissolved in blood for transport. Act on cell surface receptors - do not penetrate target cell by diffusion. Rapid onset, short duration and short half-life in the blood - usually inactivated by proteases. Not active orally. This is because they are proteins/peptides and are digested in the gut (so administration is other than oral cavity - injections!?) More is discussed below about hormone receptors B. STEROID HORMONES - Cholesterol-derived synthesized in the smooth ER. Synthesize as needed from precursors. Lipophilic and can diffuse across membranes and are not stored in secretory cell. They transported through the blood with carrier proteins. They bind on intracellular receptor (cytoplasmic or nuclear receptors (mostly)) which recognize specific steroids. Steroid hormones induce their effects by altering transcription - they activate or repress gene expression for protein synthesis. They are slower acting and have long duration and longer half-life. May be active orally Examples: cortisol, estrogen, testosterone The pineal gland, the thalamus and corpus callosum HORMONE RECEPTORS (some things are mentioned below again; this area must be cleaned!) Hormones work by binding to specific receptors on or in target cells. Receptors are specific for hormone(s). Presence of receptor is necessary for response in cell. Cells have multiple receptors for different hormones. Some hormones have more than one type of receptor; e.g. multiple types adrenergic receptor. They can get up or down regulation of receptors. Little exposure to hormone - upregulation; e.g. alloxan diabetes. Lot of exposure to a hormone - down regulation - type 2 diabetes? Agonists: substances that bind to receptor and mimic effect of a hormone. Antagonists are substances that bind to receptor but do not stimulate, so block the effect of a natural hormone. Partial agonists bind and havve low activity, phytoestrogens in soya. Many drugs act as hormone agonists/antagonists Types of hormone receptors 1. Intracellular receptors that affect mRNA transcription 2. G-protein coupled receptors 3. Tyrosine Kinase associated receptors (RTK) 1. Intracellular receptors Lipophilic hormone enters cell by simple diffusion. It binds to receptor in nucleus or cytoplasm (translocated to nucleus). Binding induces conformational change and form receptor dimers. The activated receptor has a DNA binding region that binds to ''hormone-responsive elements'' of DNA. Receptor binds to specific base sequences on DNA so affects specific genes. Binding of receptor to DNA switches genes for proteins in that area on or off. Get induction or repression of synthesis of key proteins. Calcitriol (from vitamin D) induces synthesis of several key proteins involved in calcium transport in the gut. 2. G-protein coupled receptors - GPCR Proteins in membrane with three subunits α,β and γ. They are called G proteins because they are associated with GDP/GTP. G protein complex in membrane with GDP bound to a region. Hormone binds to GPCR increases its affinity for αβγ-trimer. When GPCR and αβγ unit combine, the GDP on the α unit is replaced by GTP. The α unit when bound to GTP dissociates from βγ. The α unit binds to a membrane enzyme (or ion channel) and alters its activity. The α unit is a weak GTPase and as GTP is converted to GDP so it rebinds to form αβγ - so terminating its effects. G-proteins There are several types of G-proteins. Proteins Gs and Gi stimulate or inhibit the membrane enzyme adenylate cyclase. This catalyses ATP to cyclic AMP which is a secondary messenger which brings about intracellular hormone effects. There are other second messengers like cGMP, inositol triphosphate, diacyglycerol and calcium. Sorry for the informal diagram! Glucagon and cAMP Glucagon binds to its membrane receptor. The αβγ G protein attaches to the receptor. The α unit's GDP is replaced by GTP; this α unit detaches and binds to and activates membrane adenylate cyclase. Increased cAMP produced inside the cell. α-unit converts GTP to GDP and it rejoins to βγ-unit - cessation of effect. Cyclic AMP binds to and activates cAMP dependent protein kinase (PKA). This protein kinase adds phosphate residues to specific protein sites which activate or inhibit it. Glycogen synthase becomes inactive when phosphorylated - less glycogen synthesis. PKA phosphorylates phosphorylase kinase to make it more active and this in turn phoshorylate phosphorylate b (inactive) to an (active) increased glycogen breakdown. cAMP broken down to AMP by enzyme phosphodiesterase which stops effect. Phosphodiesterase inhibited by caffeine, theophylline and sidenafil (viagra - omg). Phosphatases within cell remove phosphate groups from protein - counteract protein kinases. Enzyme activity depends upon proportion phosphorylated - balance of kinase and phosphatase effects! cAMP A number of hormones work via cAMP as a secondary messenger. Precise effect of rise or fall in cAMP depends upon tissue enzymes. Catabolic enzymes are more active when phosphorylated i.e. by increased cAMP - anabolic less active. Theophylline potentiates effects of cAMP and is a derivative of cAMP that penetrates cell and mimics effect of cAMP (hormone?) Phosphotidyl inositol system When hormone binds to its receptor it activates a G-protein. The α subunit binds to and activates phospholipase C in membrane. This enzyme converts phospholipid phosphotidyl inositol biphosphate (PIP2) to diacylglycerol (DAG) and inositol triphosphate (IP3) - both are secondary messengers. Diacylglycerol (DAG) This activates protein kinase C in the membrane. This causes protein phosphorylation which brings about a response in the cell. Inositol Triphosphate (IP3) Enters cytoplasm. Triggers calcium release from endoplasmic reticulum. This calcium binds to a protein called calmodulin which activates a calmodulin sensitive protein kinase. Calcium can also trigger secretion. Guanylate cyclase The receptor(s) for atrial natriuretic factor (ANF) have a guanylate cyclase component. The ANF binds to the receptor which increases guanylate cyclase activity. Cyclic GMP is produced in the cell - the secondary messenger. 3. Tyrosine Kinase associated receptors (RTK) Insulin and receptor tyrosine kinase (RTK) Insulin receptor is tetramer α2β2. Insulin binds to external binding sites on a subunits. The β subunits are large transmembrane proteins with tyrosine kinase activity. The α units suppress the TK activity but when insulin binds this removes inhibition. The TK units phosphorylate each other and other cellular proteins. TK effects: activates a protein phosphatase which dephosphorylates glycogen synthase - activated. In cells like muscle and fat releases the glucose transporter GLUT-4 from vesicles to membrane. Other effects also... The hormone receptor complexes aggregate and internalised into vesicles and insulin is degraded. Feedback loop and Response loop Now lets talk abit about the how hormones are controlled Afferent: incoming signal: a. Stimulus -> b. Sensor or Receptor -> -> d. Afferent Pathway -> Efferent: outgoing signal: -> e. Integrated center -> f. Efferent pathway -> g. Target or Effector -> h. Response (this was the response loop: from stimulus to response) (Feedback loop: from response back to stimulus is the feedback loop mechanism)......Stimulus -> Sensor or receptor......etc. We gone see how this control mechanism (stimulus then sensor or receptor then afferent pathway to integrated center to efferent pathway then target or effector and response) occurs in other hormones and in different examples. Look (click) at the diagrams!!! Example 1 Example 2 Major endocrine organs Brain: - Hypothalamus (trophic and neurohormones) - Pituitary Gland (8 major hormones) Other organ sites: - Thyroid gland (thyroid hormones and calcitonin) - Adrenal cortex: cortisol and other steroids - Adrenal medulla: catecholamines - Liver: IGFs - Pancreas: insulin and glucagon - Gonads: sex hormones Neurohormone is any hormone synthesized and released by a neuron Trophic hormone is a hormone that controls the secretion of another hormone. Posterior Pituitary Summary of hormones Endocrine Control Three levels: Hypothalamic stimulation >> Hormones are synergistic and antagonistic such as the antagonism between insulin and glucagon, thyroid and parathyroid, etc.. The diagram below shows the antagonisms of hormones. Proper balance between them is extremely important for health Summary: Hormones are chemical messengers. They are synthesized, released and act at remote sites. Three main groups of hormones (proteins/peptides, steroids, amines). Each group has a different mechanism of action. Hormone release and action is controlled by response feedback loops; these loops can have multiple input and output points. Each endocrine organ makes a specific set of hormones. Hypothalamus and Pituitary gland (hormone central). Steroid hormone synthesis mainly in adrenal gland. Endocrine disorders from hormone imbalances also occur producing hyper/hypo secretion. Like the thyroid gland hyper/hypo, growth hormone production and the pancreas and insulin/glucagon balance. Also remember the importance of hormone synergy and antagonism (look at the hormone wheel diagram!) -------------------------------------------------------------------------------------------------------------- Now lets talk abit about glucose and calcium metabolism problems Insulin and Diabetes: An overview Table of Contents: History and discovery of insulin Nature of insulin and implications Actions of insulin Control of insulin secretion Glucagon actions Control of glucagon release Integrated pancreatic control of blood glucose Diabetes mellitus and its types Symptoms and long term complications Causes Pathophysiology Diagnosis Treatment Prevention Introduction - Islets of Langerhans in pancreas: α cells secrete glucagon β cells secrete insulin - Diabetes mellitus (lack of insulin) most common endocrine disorder - 1.8 million diabetics in UK (3%) 1.55 million type 2 and may be 1 million more undiagnosed (5% of NHS spending) - Pima Indians (Arizona) half population over 35 years diabetic - also very prevalent in South Asians in UK. Historical Landmarks - 150-200AD term Diabetes (syphon) applied to condition in which ''flesh and bones melt down into urine'' - 1674 the term Mellitus (honeyed) was applied because of urine's sweet taste - 1889 - Pancreatectomy in dogs produces diabetic-like state postulated that pancreas produces an antidiabetic factor. - Ligation of pancreatic duct causes degeneration of pancreas but not islets - no diabetes - 1909 the term insulin was coined but could not be isolated - 1921 Banting and Best extracted insulin from dog pancreas. - 1953 Sanger - complete sequence of insulin.1st protein to be sequenced Nature of Insulin - Protein hormone of 51 amino acids - not active by mouth. A chain is 21 aa and the B chain is 30 aa. Linkages are S-S links between cysteine residues. Pig and beef insulin are active in humans despite slight differences. First treatments were with impure animal insulin; now use ''monocomponent'' human insulin. - 1969: Proinsulin extracted from pancreas. Single chain of 84aa and C-peptide (33aa) cut out to leave insulin i.e. 1 gene. C-peptide used as a marker for endogenous insulin production in diabetes. Actions of Insulin - Increased synthesis glycogen, fat and protein. - Increased glucose uptake into muscle and adipose tissue but not brain, liver, red cells, etc. - Increased glycogen formation and glucose use - Increased fat synthesis - Increased protein synthesis in muscle - Reduced ketone production - So lack of insulin......... Control of insulin secretion Increases in blood glucose (and blood amino acids) have direct effect on β-cell. GIP produced by gut in response to eating increases insulin release - anticipatory. Parasympathetic stimulation (vagus) increases release but sympathetic reduces it. Glucagon 29 amino acid peptide from α-cells. Increases glycogen breakdown and gluconeogenesis in liver. Release is stimulated by low blood glucose. High blood amino acids increases release but this is suppressed by high blood glucose. Increases by sympathetic or parasympathetic activity, DIABETES Diagnosis - Symptoms plus casual plasma glucose 11.1mmol/l. - Fasting (8h+) plasma glucose 7.0mmol/l (6.1 for whole blood). - 2h plasma glucose 11.1mmol/l during oral glucose (75g) tolerance test. - 6.1-7mmol fasting impaired - half will become diabetic within 10yrs - No symptoms - need to repeat Type 1 diabetes Type 1 diabetes - Less than 10% of total - Characterized by β-cell destruction and almost total failure of insulin supply. Fairly rapid onset usually in childhood. Need isnulin injections and prone to ketoacidosis - Often thin at diagnosis. Inherited predisposition (linked to tissue-type) - environmental trigger(s) e.g. infection - Most have autoantibodies to β-cells at diagnosis Type 2 diabetes Type 2 Diabetes - No initial β-cell degeneration. Gradual onset traditionally in people over 40 but starting to occur in young - why? - Usually overweight at diagnosis - Symptoms relatively mild at start and ketoacidosis uncommon (undiagnosed) - Most do not need insulin unless advanced - Runs in families but not linked to tissue type and no islet cell antibodies present - Prevalence increasing as population ages and gets fatter Causes of type 2 diabetes: - No initial β-cell pathology and insulin still produced (absolute level may be high) - Reduced sensitivity to insulin - need more to get same effect - Genetic susceptibility - racial differences - Environmental triggers - ''western diet and lifestyle'' high fat diet; inactivity; overweight and abdominal obesity Metabolic syndrome (syndrome X) - Insulin resistance causes problems even without diabetes: high blood insulin, moderate hyperglycaemia, hypertension, raised blood TAg and lowered HDL. - Many later become diabetic and all at increased risk of CHD Diagnosis High waist (102cm men or 88cm women) or WHR 0.95/0.85 Moderate fasting hyperglycaemia Elevated BP Elevated TAG Low HDL ANY THREE suggests diagnosis Symptoms of Diabetes Mellitus Symptoms of diabetes mellitus High blood glucose (diagnosis) – why?? Glucose in urine – why?? Diuresis – why?? Prone to dehydration despite increased thirst and drinking In type 1 get ketoacidosis: Fatty acids →Acetyl CoA → Ketones Rapid weight loss (may also occur in type 2 so underestimate link with obesity) Hypoglycaemic coma? Long term complication Diabetics tend to die prematurely despite effective short term treatment Very high rates of cardiovascular disease – insulin resistance (pre-diabetes) is a risk factor for heart disease Also prone to retinopathy and cataracts – blindness Diabetic nephropathy (renal failure) Gangrene and risk of amputation Causes of long term problems High levels of blood lipoproteins causing increased risk of atherosclerosis in arteries Changes in functioning of small blood vessels due to persistent hyperglycaemia and glycosylation of protein in membranes Latter thought to be important factor in retinopathy and renal failure To improve long term prospects Normalise blood lipoprotein profile Normalise body weight Minimise the hyperglycaemia without repeated bouts of hypoglycaemia Diagnose and treat hidden cases because long term damage is ongoing Implementation Low (saturated) fat diet – prior to 1970 diabetic diet was high fat low carbohydrate. sSubstitution of complex for simple carbohydrates, increase in dietary fibre, restriction of energy intake (when necessary) This helps to normalise blood lipoproteins but also improves insulin sensitivity Rapid self monitoring of blood glucose Long term check – glycosylated haemoglobin Use of rapid soluble insulin and prolonged action depot insulin Oral hypoglycaemic agents Sulponylureas act to stimulate insulin release (e.g. tolbutamide and chlorpropamide) – only work in type 2 where there are functioning β-cells Biguanides – reduces hepatic gluconeogenesis, slows absorption from gut and increases uptake by muscle 2 Trials Diabetes Control and Complications Trial DCCT) for type 1 UK Prospective Diabetes Survey - type 2 Development renal, retinal & neuropathy delayed by intensified therapy Higher glycated Hb – more complications & deaths Calcium and Osteo Calcium Balance - Overview of typical calcium fluxes - Vitamin D – nature and role - Role of parathyroid hormone - Role of calcitonin - Integrated control of blood calcium - Osteoporosis - What is it? - What causes it? - What can be done about it? Calcium For adults: Gains – losses = 0 Growth & pregnancy – net gain Gains and losses hormonally controlled 99% of body calcium is in bone mineral as hydroxyapatite – c1kg Bone is a reserve of calcium – release or uptake of Ca2+ hormonally controlled Functions of non-bone calcium Muscle contraction – excitation triggers Ca2+ release which triggers contraction Hormone/transmitter release Intracellular regulator Co-enzyme function – blood clotting Etc So blood calcium finely regulated and must be kept within narrow limits Osteoporosis Thinning of bones making them susceptible to fracture e.g. from simple fall Up to 3 million people in UK may be affected – annual toll of: 70,000 hip fractures 40,000 recorded vertebral fractires 50,000 wrist fractures c20,000 death each year attributable to hip fractures Nature of osteoporosis Osteoclasts – breakdown of bone Osteoblasts – make new bone Bone constantly being remodelled but in later life synthesis slightly less than breakdown so gradual erosion Risk factors for osteoporosis Bone mass declines with age acceleration at menopause (more elderly women more osteoporosis) Inactivity – weight bearing exercise increases bone mass and inactivity leads to loss of bone Lack of sex hormones (even in men)– early menopause, anorexia etc Lack of vitamin D (sunlight exposure) What about calcium intake?? Smoking, heavy drinking, being underweight Osteoporosis – strategies for reducing its effects Increase peak bone mass – e.g. encourage activity in children and young adults Slow decline in bone mass – activity, vitamin D, HRT in older people also drugs that block bone breakdown Reduce risk of falling – building design and maintenance, maintain muscle strength, protect hips with padding? Increase bone strength – reverse process of oseoporosis Conventional treatments Oestrogen therapy – good preventative Vitamin D/calcium - 40% of old people in residential homes have biochemical evidence of vit. D deficiency Calcitonin as nasal spray or by injection – blocks bone breakdown Biphosphonates are analogues of pyrophosphate (etidronate and alendronate) adsorbed onto bone mineral and inhibit resorption Teriparatide – new treatment Active parathyroid analogue which is injected Leads to formation of strong new bone – reverses osteoporosis Treatment for up to 18 months and benefits last beyond this Theory: Pth leads to increased renal Ca2+ reabsorption, vit D activation and bone breakdown – but latter only at high doses At low doses Pth stimulates osteoblasts (bone makers) before osteoclasts (bone breakers) HRT HRT has been first line preventative for osteoporosis Endometrial cancer is a clear risk of oestrogen alone so must give with synthetic progestin if uterus present Conclusively show to reduce bone loss in postmenopausal women Case-control studies – up to 50% reduction in hip fractures in menopausal women taking oestrogen More problems with HRT Nelson et al (2002) – HRT increased risk of heart disease in elderly women Beral et al (2003) Million women study – HRT small increase in breast cancer risk 2003 MHRA advised GPs that HRT should not be used for long periods to prevent osteoporosis in women over 50 Phyto-oestrogens Are these an alternative to HRT? Substances from plants not steroids but have oestrogenic activity Isoflavins (genistein, daidzein) from soy and other legumes Lignans in whole grains Coumestins in clover and alfalfa sprouts Soy foods and supplements, blach cohosh, red clover 2-4 mg isoflavins per mg soy protein Supplements c40mg/day Some diets high in soy 100mg/day Babies soy formula 4mg/kg body weight Act as partial agonists so can increase or decrease oestrogenic activity depending upon circumstances c1:10,000 potency of oestrogen But HRT c50μg/day whereas supps 1000X more by weight of isoflavins So significant total activity Branca 2003 In vitro genistein reduces osteoclast activity but increases osteoblasts Soybean feeding increases bone density in ovariectomised rats Women in SE Asia (where soy intakes are high) – women with highest intakes have higher bone density Not seen where soy intakes are lower (need high dose) Review of 7 studies suggest phyto-oestrogens over 6 months positive influence on bone density in lumbar spine Phyto-oestrogens – substantial report published by Food Standards Agency Other benefits? Possible risks?
Use these affirmations for hormonal balance to soothe your mind and body. Also get quick tips on what is good to take for hormone balance.
There are so many sneaky things that could be causing your hormone imbalance. Learn what to avoid & what to change to support your hormones.
Alongside poor gut health, bad hormonal health is one of the top contributing factors to health issues in women. This article discusses natural solutions for women’s hormone imbalances. What causes, increased body weight, hot flashes, night sweats, cravings, lack of sleep in women especially those going through perimenopause and menopause? The answer is hormonal imbalance!...
There is no one cause for all hormonal imbalances, but most commonly for women, hormonal imbalances occur around puberty, teens to early 20s, pregnancy, and menopause. Any high-stress or traumatic experience can also cause a hormonal imbalance and be overweight for a long time without being treated.
The basics of hormone health, the main factors that influence women's hormone balance and lifestyle choices you can make to improve yours.
5 herbal Supplements to help you balance your hormones, naturally. These supplements help balance female hormones without over the counter meds.
Nicole Brors, CNC, CCMH + Women's Health Coach, focused on improving the metabolism, balancing hormones and increasing energy by getting to the root case
Discover the Science Behind Hormonal Weight Loss and the Breakthrough 30-Second Fix That Transforms Bodies in Record Time In the constant pursuit of achieving our ideal weight, we often encounter numerous roadblocks that seem insurmountable. However, what if I told you that there's a revolutionary solution capable of addressing these barriers head-on? Welcome to the world of "The 5 Hormonal Blocks," a groundbreaking approach to weight loss that targets the root cause of your struggles. In this comprehensive review, we'll delve deep into the science behind hormonal weight loss and unveil the transformative power of the 30-Second Fix that has left countless individuals amazed by its efficacy. Introduction: Unravelling the Mystery of Hormonal Weight Loss Weight loss is not merely about counting calories or sweating it out at the gym; it's a complex interplay of biological factors that influence our body's ability to shed excess pounds. 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One of the top questions I get asked is what I recommend to help the body fix itself, at a foundational level. Perhaps you are craving this knowledge, and want nothing…
